FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\FXR2UAS.Tag:MYC
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General Information
Symbol
Hsap\FXR2UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0284062
Feature type
allele
Associated gene
Hsap\FXR2
Associated Insertion(s)
Carried in Construct
P{UAS-hFXR2.MYC}
Key Links
Transgenic product class
wild_type
(Coffee et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Coffee et al., 2010)
Mutagen
in vitro construct
(Coffee et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-hFXR2.MYC}
Cytology
Description

UASt drives drive expression of Hsap\FXR2 tagged with Tag:MYC.

(Coffee et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\FXR2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Hsap\FXR2UAS.Tag:MYC/Scer\GAL4VP16.nanos.UTR is a suppressor of male sterile phenotype of Fmr1Δ50M

      (Coffee et al., 2010)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4elav-C155/Hsap\FXR2UAS.Tag:MYC is a non-suppressor of abnormal neuroanatomy phenotype of Fmr1Δ50M

      (Coffee et al., 2010)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\FXR2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 fails to suppress the synaptic overgrowth defects characterising Fmr1Δ50M mutants.

      Expression of Hsap\FXR2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4elav-C155 fails to suppress the enlarged neuromuscular junctional area and increased synaptic branching that characterise Fmr1Δ50M mutants.

      Pre-synaptic expression of Hsap\FXR2Scer\UAS.T:Hsap\MYC using Scer\GAL4elav-C155 is totally incapable of restoring bouton number to control levels in Fmr1Δ50M mutants.

      Scer\GAL4elav-C155>Hsap\FXR2Scer\UAS.T:Hsap\MYC is totally incapable of restoring the elevated mini-bouton number in Fmr1Δ50M mutants.

      Expression of Hsap\FXR2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 completely suppresses the male fecundity phenotype that characterises Fmr1Δ50M mutants.

      Expression of Hsap\FXR2Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 can fully restore the spermatid axoneme architecture in Fmr1Δ50M mutants.

      (Coffee et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\FXR2Scer\UAS.T:Hsap\MYC
      Hsap\FXR2UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)