FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\su(Hw)mF10-LexA.Act5C
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General Information
Symbol
Dmel\su(Hw)mF10-LexA.Act5C
Species
D. melanogaster
Name
FlyBase ID
FBal0284144
Feature type
allele
Associated gene
Dmel\su(Hw)
Associated Insertion(s)
Carried in Construct
P{Act5C-su(Hw).LexA.mF10}
Key Links
Transgenic product class
missense_variant
(Kuhn-Parnell et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kuhn-Parnell et al., 2008)
Mutagen
in vitro construct
(Kuhn-Parnell et al., 2008)
Progenitor genotype
Carried in construct
P{Act5C-su(Hw).LexA.mF10}
Cytology
Description

The Act5C promoter drives expression of a mutant form of the su(Hw) coding sequence carrying a C525Y mutation in zinc finger 10 and fused to the 202aa Ecol\lexA DNA-binding domain.

(Kuhn-Parnell et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Act5C
Encoded product / tool
su(Hw)
Tagged with
lexA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies co-expressing su(Hw)mF10.Act5C.T:Ecol\lexA and wLexABR.En exhibit weak eye colour phenotypes. 4/5 insertion lines show some degree of pigmentation loss.

      Flies co-expressing su(Hw)mF10.Act5C.T:Ecol\lexA and yLexABR.En exhibit cuticle pigmentation defects. 2/5 insertion lines examined show light pigmentation.

      Co-expression of su(Hw)mF10.Act5C.T:Ecol\lexA partially suppresses the eye color defects seen in flies expressing wLexABR.UbxPRE. Darker eye colours are observed in all insertion lines examined.

      Co-expression of su(Hw)mF10.Act5C.T:Ecol\lexA partially suppresses the cuticle pigmentation defects seen in flies expressing yLexABR.UbxPRE. Darker pigmentation is observed in 2/5 insertion lines examined.

      (Kuhn-Parnell et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      su(Hw)mF10-LexA.Act5C
      su(Hw)mF10.Act5C.T:Ecol\lexA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)