FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mtrmUASp.FL.Tag:FLAG
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General Information
Symbol
Dmel\mtrmUASp.FL.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0284261
Feature type
allele
Associated gene
Dmel\mtrm
Associated Insertion(s)
Carried in Construct
P{UASp-mtrm.FL.3XFLAG}
Key Links
Transgenic product class
wild_type
(Bonner et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bonner et al., 2013)
Mutagen
in vitro construct
(Bonner et al., 2013)
Progenitor genotype
Carried in construct
P{UASp-mtrm.FL.3XFLAG}
Cytology
Description

UASp regulatory sequences drive expression of full-length mtrm which is tagged with Tag:FLAG.

(Bonner et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
mtrm
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from females expressing mtrmScer\UAS.FL.T:Zzzz\FLAG under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show defects in approximately 20% of cases. The defects seen include 'nuclear fallout' (nuclei at the surface detach from their centromeres and fall back into the middle of the embryos), 'mitotic catastrophe' (embryos have only scattered DNA with no real spindle organisation: some contain DNA over the entire expanse of the embryo, while others only contain DNA in a particular section of the embryo) and 'uneven development' (part of the embryo contains only scattered DNA, the other part appears to reach the blastoderm stage).

      (Whitfield et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The defects seen in embryos derived from females expressing mtrmScer\UAS.FL.T:Zzzz\FLAG under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show higher penetrance and are more severe if the females are also heterozygous for polo11.

      (Whitfield et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4VP16.nanos.UTR/mtrmUASp.FL.Tag:FLAG rescues Df(3L)66C-T2-10/+

      (Bonner et al., 2013)
      Comments

      The X and 4th chromosome nondisjunction defects seen in FM7/X females heterozygous for Df(3L)66C-T2-10 are rescued by expression of mtrmScer\UAS.FL.T:Zzzz\FLAG under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

      (Bonner et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mtrmFL
      (Bonner et al., 2013)
      mtrmScer\UAS.FL.T:Zzzz\FLAG
      mtrmUASp.FL.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)