The expression of Hsap\LRRK2^{G2019S.K1906M.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^ple.TH-D', but not Scer\GAL4^ple.PF, Scer\GAL4^nSyb.PG, Scer\GAL4^Gr5a.8.5, Scer\GAL4^E49, Scer\GAL4^Ddc.PL, Scer\GAL4^Ddc.HL9or Scer\GAL4^ple.TH-C', leads to a significant decrease in proboscis extension reflex (in starved flies exposed to a moderate sugar stimulus), as compared to controls.

As in controls, the dynamic golgi outposts (GOPs) in the dendrites of dendritic arborizing neurons expressing Hsap\LRRK2^{G2019S.K1906M.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^ppk.PU show an overall preference for retrograde movement (towards cell bodies), but show an increase in retrograde displacement. The displacement of GOPs moving in the anterograde direction (towards dendritic ends) is also increased compared with controls. Velocity of movement is increased in the anterograde direction compared with controls.

Flies expressing Hsap\LRRK2^{G2019S.K1906M.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^ple.PG do not show a progressive reduction in electroretinogram amplitude (there is no significant difference in the amplitude seen in 3 and 28 day old flies).

Expression of Hsap\LRRK2^{G2019S.K1906M.Scer\UAS.T:Zzzz\FLAG} in dendritic arborization (DA) neurons using Scer\GAL4^109(2)80 engenders dendrite arborization defects as shown by the quantification of numbers of dendritic ends in the dorsal field of A6 segments in third instar larvae.

Axonal terminals of class IV dendritic arborizing neurons expressing Scer\GAL4^ppk.PG>Hsap\LRRK2^{G2019S.K1906M.Scer\UAS.T:Zzzz\FLAG} remain normal, targeting to the ventral nerve cord, although the complexity of dendrites is severely compromised, displaying shorter and fewer terminal arbors and leaving some receptive fields uncovered.