FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RyRGS21220
Open Close
General Information
Symbol
Dmel\RyRGS21220
Species
D. melanogaster
Name
FlyBase ID
FBal0284362
Feature type
allele
Associated gene
Dmel\RyR
Associated Insertion(s)
P{GSV7}RyRGS21220
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Gao et al., 2013)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV7}RyRGS21220
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV7}
    Regulatory region(s)
    UASt
    Also carries
    loxP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Heterozygotes, homozygotes, RyRΔ25/RyRGS21220 and RyRk04913/RyRGS21220 animals show resistance to halothane compared to wild type.

        RyRk04913/RyRGS21220 animals show resistance to sevoflurane, enflurane and isoflurane compared to wild type.

        Heterozygotes show resistance to enflurane compared to wild type.

        RyRΔ25/RyRGS21220 adults are significantly less active than wild-type flies.

        (Gao et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        RyRGS21220 is rescued by RyR+tCH321-24D03

        (Gao et al., 2013)

        RyRGS21220/RyRk04913 is rescued by RyRUAS.Tag:V5/Scer\GAL4nrv2.PS

        (Gao et al., 2013)
        Comments

        RyR+tCH321-24D03 rescues the halothane-resistant phenotype of RyRGS21220/+ animals.

        Expression of RyRScer\UAS.T:SV5\V5 under the control of Scer\GAL4nrv2.PS restores sensitivity to halothane in RyRk04913/RyRGS21220 animals.

        (Gao et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        RyRGS21220
        dRyrGS21220
        (Gao et al., 2013)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)