FB2026_03 , released September 17, 2026
Allele: Dmel\RyR+tCH321-24D03
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General Information
Symbol
Dmel\RyR+tCH321-24D03
Species
D. melanogaster
Name
FlyBase ID
FBal0284364
Feature type
allele
Associated gene
Dmel\RyR
Associated Insertion(s)
Carried in Construct
PBac{CH321-24D03}
Key Links
Transgenic product class
genomic_DNA
(Gao et al., 2013)
wild_type
(Gao et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Gao et al., 2013)
wild_type
(Gao et al., 2013)
Mutagen
in vitro construct
(Gao et al., 2013)
Progenitor genotype
Carried in construct
PBac{CH321-24D03}
Cytology
Description

Pacman clone CH321-24D03, which includes RyR.

(Gao et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
RyR
Encoded product / tool
RyR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals carrying a single copy of RyR+tCH321-24D03 in a wild-type background show significant hypersensitivity to halothane compared to wild-type controls.

      The addition of more than one copy of RyR+tCH321-24D03 in a wild-type background results in lethality.

      (Gao et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      RyR+tCH321-24D03 rescues RyRGS21220

      (Gao et al., 2013)
      Comments

      RyR+tCH321-24D03 rescues the halothane-resistant phenotype of RyRGS21220/+ animals.

      (Gao et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      RyR+tCH321-24D03
      RyR24D03
      (Wong et al., 2021)
      dRyr24D03
      (Gao et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)