FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AlkRNAi.WIZ.UAS
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General Information
Symbol
Dmel\AlkRNAi.WIZ.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0284379
Feature type
allele
Associated gene
Dmel\Alk
Associated Insertion(s)
Carried in Construct
P{UAS-Alk.RNAi.WIZ}
Key Links
Transgenic product class
RNAi_reagent
(Rohrbough et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Rohrbough et al., 2013)
Mutagen
in vitro construct
(Rohrbough et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Alk.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of a 3141bp fragment from the Alk coding sequence.

(Rohrbough et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Alk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately one-third of newly hatched larvae expressing AlkdsRNA.WIZ.Scer\UAS under the simultaneous control of both Scer\GAL4twi.PG and Scer\GAL4how-24B have gut defects.

      Neuromuscular junction (NMJ) size, elaboration and bouton density appears normal in third instar larvae expressing AlkdsRNA.WIZ.Scer\UAS under the simultaneous control of both Scer\GAL4twi.PG and Scer\GAL4how-24B. However, the mean evoked excitatory junctional potential (EJP) amplitude at the NMJ is increased 20% compared to controls.

      (Rohrbough et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AlkRNAi.WIZ.UAS
      AlkdsRNA.WIZ.Scer\UAS
      AlkdsRNA.WIZ.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)