FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\p53+tTa
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General Information
Symbol
Dmel\p53+tTa
Species
D. melanogaster
Name
FlyBase ID
FBal0284408
Feature type
allele
Associated gene
Dmel\p53
Associated Insertion(s)
Carried in Construct
P{p53+tTa}
Also Known As
P{p53+}
Key Links
Genomic Maps

Transgenic product class
genomic_DNA
(Titen and Golic, 2008)
wild_type
(Titen and Golic, 2008)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Titen and Golic, 2008)
wild_type
(Titen and Golic, 2008)
Mutagen
in vitro construct
(Titen and Golic, 2008)
Progenitor genotype
Carried in construct
P{p53+tTa}
Cytology
Description

An approximately 7.9kb genome fragment containing the wild type p53 gene with 3.2kb of putative 5' UTR and 1.2kb of putative 3'UTR sequences.

(Titen and Golic, 2008)
Allele components
Component
Use(s)
Regulatory region(s)
p53
Encoded product / tool
p53
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
rescue_region
3R:23,048,740..23,056,596 [-]
Comment:

The 7.9 kb genomic fragment contains 3.2 kb upstream and 1.2 kb downstream of p53.

(Titen and Golic, 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      p53+tTa rescues p535A-1-4

      (Titen and Golic, 2008)
      Comments

      Expression of p53+tTa rescues the partial suppression of apoptosis seen in p535A-1-4 mutant cells containing dicentric chromosomes (generated using Scer\FLP1hs.PP-induced recombination in chromosomes containing inverted Scer\FRT sites).

      (Titen and Golic, 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      p53+tTa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)