FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mAcon1S677A.UAS
Open Close
General Information
Symbol
Dmel\mAcon1S677A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0284599
Feature type
allele
Associated gene
Dmel\mAcon1
Associated Insertion(s)
Carried in Construct
PBac{UAS-mAcon1.S677A}
Key Links
Transgenic product class
missense_variant
(Esposito et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Esposito et al., 2013)
Mutagen
in vitro construct
(Esposito et al., 2013)
Progenitor genotype
Carried in construct
PBac{UAS-mAcon1.S677A}
Cytology
Description

UASt regulatory sequences drive expression of Acon containing the amino acid replacement S677A. This results in a catalytically inactive protein that still harbours its "["4Fe-4S"]" cluster.

(Esposito et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mAcon1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AconS677A.Scer\UAS under the control of Scer\GAL4ple.PF in dopaminergic neurons results in mitochondria forming fragmented spherical aggregates instead of the long tubular network of mitochondria seen in wild type.

      (Esposito et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Drp1+t9.4 or parkScer\UAS.T:Ivir\HA1 does not rescue the defects in mitochondrial morphology seen in dopaminergic neurons expressing AconS677A.Scer\UAS under the control of Scer\GAL4ple.PF.

      (Esposito et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AconS677A.Scer\UAS
      AconS677A.UAS
      mAcon1S677A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)