FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Atx2ΔPAM2.UAS.Tag:FLAG
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General Information
Symbol
Dmel\Atx2ΔPAM2.UAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0285120
Feature type
allele
Associated gene
Dmel\Atx2
Associated Insertion(s)
Carried in Construct
P{UAS-Atx2.ΔPAM2.FLAG}
Key Links
Transgenic product class
inframe_deletion
(Lim and Allada, 2013)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Lim and Allada, 2013)
Mutagen
in vitro construct
(Lim and Allada, 2013)
Progenitor genotype
Carried in construct
P{UAS-Atx2.ΔPAM2.FLAG}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Atx2 lacking the PAM2 domain. The construct is tagged at the C-terminal end with 3xTag:FLAG.

(Lim and Allada, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Atx2
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Machado-Joseph disease
      modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
      (Xu et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Depending on the insertion, the expression of Atx2ΔPAM2.UAS.Tag:FLAG under the control of Scer\GAL4P2.4.Pdf leads to a moderate impairment of circadian behavior, as compared to controls.

      (Xu et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expressing Hsap\HTTQ25.ex1p.UAS.EGFP and Atx2ΔPAM2.UAS.Tag:FLAG under the control of Scer\GAL4P2.4.Pdf severely impairs circadian behavior, as compared to Hsap\HTTQ25.ex1p.UAS.EGFP and wild-type controls.

      (Xu et al., 2019)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Atx2ΔPAM2.Scer\UAS.T:Zzzz\FLAG
      Atx2ΔPAM2.UAS.Tag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (2)