FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\HTTQ25.ex1p.UAS.EGFP
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General Information
Symbol
Hsap\HTTQ25.ex1p.UAS.EGFP
Species
H. sapiens
Name
FlyBase ID
FBal0294195
Feature type
allele
Associated gene
Hsap\HTT
Associated Insertion(s)
Carried in Construct
P{UAS-Httex1p-Q25-eGFP}
Also Known As
UAS-HTTex1-25Q-eGFP
Key Links
Transgenic product class
wild_type
(Zhang et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zhang et al., 2010)
Mutagen
in vitro construct
(Zhang et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Httex1p-Q25-eGFP}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\HTT exon 1 containing a 25 residue polyQ tract (wild-type). The protein is tagged at the C-terminal end with EGFP.

(Zhang et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\HTT
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Huntington's disease
      CEA
      (White et al., 2020)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Hsap\HTTQ25.ex1p.UAS.EGFP under the control of Scer\GAL4P2.4.Pdf does not seem to have a major effect on circadian behavior, nor on the number of sLNv neurons.

      (Xu et al., 2019)

      3 week old flies expressing Hsap\HTTQ25.ex1p.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4HCH.Hand show no significant difference in heart function (quantified by systolic diameter, diastolic diameter, systolic interval, diastolic interval, fractional shortening and arrhymicity index) compared to controls.

      (Melkani et al., 2013)

      Aggregates of Hsap\HTT protein are not seen in the eyes of flies expressing Hsap\HTTQ25.ex1p.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.PU.

      (Zhang et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expressing Hsap\HTTQ25.ex1p.UAS.EGFP and Atx2UAS.Tag:FLAG, Hsap\HTTQ25.ex1p.UAS.EGFP and Atx2ΔPAM2.UAS.Tag:FLAG, or Hsap\HTTQ25.ex1p.UAS.EGFP and Atx2ΔLsm.UAS.Tag:FLAG, under the control of Scer\GAL4P2.4.Pdf, severely impairs circadian behavior, as compared to Hsap\HTTQ25.ex1p.UAS.EGFP and wild-type controls.

      (Xu et al., 2019)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\HTTQ25.ex1p.Scer\UAS.T:Avic\GFP-EGFP
      Hsap\HTTQ25.ex1p.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (8)