FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SMC6jnj-R1
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General Information
Symbol
Dmel\SMC6jnj-R1
Species
D. melanogaster
Name
FlyBase ID
FBal0285376
Feature type
allele
Associated gene
Dmel\SMC6
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Li et al., 2013)
Progenitor genotype
Cytology
Description

4p deletion in the second coding exon, removing ATCT at position 334-337bp from the presumptive start codon. This results in a frameshift, producing a stop codon at position 133.

(Li et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:24,192,839..24,192,842 [-]
Comment:

Deletion of 4 bp (ATCT) in the second coding exon of jnj.

(Li et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant eyes (generated using the "EGUF" method) show morphological defects when animals are raised on medium containing 2mM caffeine.

      Homozygotes show caffeine-dependent pupal lethality.

      Homozygotes, jnjR1/jnjX1 and jnjR1/Df(3R)Exel6198 animals show reduced survival after irradiation compared to controls.

      Dramatically increased apoptotic cell death is observed in the eye discs of jnjR1/jnjX1 larvae after 12 hours exposure to caffeine.

      BrdU incorporation in eye imaginal discs is abolished by hydroxyurea treatment in jnjR1/jnjX1 larvae, as occurs in wild type.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      SMC6huc95E

      (Li et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SMC6jnj-R1
      jnjR1
      (Li et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)