FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SMC6jnj-X1
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General Information
Symbol
Dmel\SMC6jnj-X1
Species
D. melanogaster
Name
FlyBase ID
FBal0285377
Feature type
allele
Associated gene
Dmel\SMC6
Associated Insertion(s)
P{?GawB}SMC6jnj-X1
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Li et al., 2013)
Progenitor genotype
P{GawB}NP2592
(Li et al., 2013)
Associated Insertion(s)
P{?GawB}SMC6jnj-X1
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion of 473bp of genomic sequence (coordinates 3R:20019151..20018679 , release 5 genome). 12bp of the original insertion remain.

(Li et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:24,192,957..24,193,429 [-]
Comment:

473 bp deletion resulting from the imprecise excision of P{GawB}NP2592. 12 bp (CATGATGAAATA) of the P element remain.

(Li et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes and jnjX1/jnjR1 animals show caffeine-dependent lethality.

      Homozygotes, jnjR1/jnjX1 and jnjR1/Df(3R)Exel6198 animals show reduced survival after irradiation compared to controls.

      Dramatically increased apoptotic cell death is observed in the eye discs of jnjR1/jnjX1 larvae after 12 hours exposure to caffeine.

      BrdU incorporation in eye imaginal discs is abolished by hydroxyurea treatment in jnjR1/jnjX1 larvae, as occurs in wild type.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SMC6jnj-X1
      jnjX1
      (Li et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)