FlyBase Allele Report: Dmel\nAChRα7[UAS.cMa]

General Information

Symbol

Dmel\nAChRα7^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Mejia

FlyBase ID

FBal0285439

Feature type

allele

Associated gene

Dmel\nAChRα7

Associated Insertion(s)

Carried in Construct

P{UAS-nAChRα7.M}

Also Known As

UAS-Dα7

Key Links

Transgenic product class

wild_type

(Mejia et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Mejia et al., 2013)

Mutagen

in vitro construct

(Mejia et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-nAChRα7.M}

Cytology

Description

UASt regulatory sequences drive expression of wild-type nAChRα7.

(Mejia et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

nAChRα7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of gfA^Scer\UAS.cMa under the control of Scer\GAL4^OK307 has no effect on the function of the giant fiber - dorsal longitudinal pathway circuit.

Expression of gfA^Scer\UAS.cMa under the control of Scer\GAL4^OK307 has no significant effect on the latency of the response of the tergotrochanteral muscle to stimulation of the giant fiber.

(Mejia et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

nAChRα7^UAS.cMa/Scer\GAL4^shot-OK307 rescues nAChRα7^PΔEY6

(Mejia et al., 2013)

Comments

Expression of gfA^Scer\UAS.cMa under the control of Scer\GAL4^OK307 rescues the responses of the dorsal longitudinal muscle to stimulation of the giant fiber to wild type (the refractory period and maximum following frequency are normal).

(Mejia et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

64147

w^*; P{UAS-nAChRα7.M}2

64148

w^*; P{UAS-nAChRα7.M}3

Notes on Origin

Discoverer