FlyBase Gene Report: Dmel\nAChRα7

General Information

Symbol

Dmel\nAChRα7

Species

D. melanogaster

Name

nicotinic Acetylcholine Receptor α7

Annotation Symbol

CG32538

Feature Type

protein_coding_gene

FlyBase ID

FBgn0086778

Gene Model Status

Current

Stock Availability

35 publicly available

Gene Summary

nicotinic Acetylcholine Receptor α7 (nAChRα7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

Dα7, gfA, nAcRα-18C, nAChR, giant fibre A

Key Links

Genomic Location

Cytogenetic map

18C2-18C3

Sequence location

X:19,327,075..19,348,447 [-]

Recombination map

1-62

RefSeq locus

NC_004354 REGION:19327075..19348447

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (24 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables acetylcholine-gated monoatomic cation-selective channel activity

inferred from direct assay

(Lansdell et al., 2012)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables acetylcholine-gated monoatomic cation-selective channel activity

inferred from electronic annotation with InterPro:IPR002394

(InterPro Project Members, 2004-)

enables extracellular ligand-gated monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR006202, InterPro:IPR036734

(InterPro Project Members, 2004-)

enables monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR002394, InterPro:IPR006201

(InterPro Project Members, 2004-)

enables neurotransmitter receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000434994

(GO Reference Genome Project, 2011-)

enables transmembrane signaling receptor activity

inferred from electronic annotation with InterPro:IPR006201

(InterPro Project Members, 2004-)

Biological Process (10 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in chemical synaptic transmission

inferred from mutant phenotype

(Fayyazuddin et al., 2006, Thomas and Wyman, 1984)

involved_in excitatory postsynaptic potential

inferred from mutant phenotype

(Fayyazuddin et al., 2006)

involved_in jump response

inferred from mutant phenotype

(Fayyazuddin et al., 2006, Thomas and Wyman, 1984)

involved_in monoatomic cation transport

inferred from direct assay

(Lansdell et al., 2012)

involved_in synaptic transmission, cholinergic

inferred from expression pattern

(Takemura et al., 2011)

involved_in visual behavior

inferred from mutant phenotype

(Fayyazuddin et al., 2006)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in calcium ion transport

inferred from biological aspect of ancestor with PANTHER:PTN000434994

(GO Reference Genome Project, 2011-)

involved_in monoatomic ion transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000434994

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR006201

(InterPro Project Members, 2004-)

involved_in monoatomic ion transport

inferred from electronic annotation with InterPro:IPR002394, InterPro:IPR006029, InterPro:IPR006202, InterPro:IPR036719, InterPro:IPR036734

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR002394, InterPro:IPR006202, InterPro:IPR036734

(InterPro Project Members, 2004-)

involved_in regulation of membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN000434994

(GO Reference Genome Project, 2011-)

involved_in synaptic transmission, cholinergic

inferred from biological aspect of ancestor with PANTHER:PTN001054960

(GO Reference Genome Project, 2011-)

Cellular Component (9 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

part_of acetylcholine-gated channel complex

inferred from physical interaction with FLYBASE:nAChRα5; FB:FBgn0028875,FLYBASE:nAChRα6; FB:FBgn0032151

(Lansdell et al., 2012)

located_in dendrite

inferred from direct assay

(Fayyazuddin et al., 2006)

located_in dendritic spine

inferred from direct assay

(Leiss et al., 2009)

located_in postsynaptic density

inferred from direct assay

(Kremer et al., 2010)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

part_of acetylcholine-gated channel complex

inferred from biological aspect of ancestor with PANTHER:PTN001825278

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR002394, InterPro:IPR006029, InterPro:IPR006201, InterPro:IPR006202, InterPro:IPR036719, InterPro:IPR036734

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR002394, InterPro:IPR006201, InterPro:IPR006202, InterPro:IPR036734

(InterPro Project Members, 2004-)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN000434994

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001054635

(GO Reference Genome Project, 2011-)

located_in postsynaptic membrane

inferred from electronic annotation with InterPro:IPR002394

(InterPro Project Members, 2004-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN000434994

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNITS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

nicotinic Acetylcholine Receptor α7 (nAChRα7) encodes a subunit of the nicotinic acetylcholine receptor, a pentameric neurotransmitter-gated ion channel. [Date last reviewed: 2019-02-28]

Gene Group (FlyBase)

NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNITS -: Nicotinic ligand-gated ion channels (nAChR) mediate the fast actions of the acetylcholine (ACh). The non-selective ion channel is formed from five subunits arranged around a central pore. The ACh binding site is formed by two adjacent α subunits. Other regulatory subunits may modulate channel pharmacology and expression. (Adapted from FBrf0183743).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

gfA: giant fiber A (J.C. Hall; R.A. Wyman)

Adults have an aberrant startle response; they do not jump when presented with a lights-off stimulus. The dorso-longitudinal indirect flight muscles (DLMs) are abnormally driven by the giant fiber pathway neurons (see entry for ben). DLMs are driven at long and variable latencies after brain stimulation. Morphology of the giant fiber and its response to stimulation is normal. The motor neuron of the tergotrochanteral (jump) muscle is driven normally by the giant fiber. The physiological defect in gfA is probably located at the synapses between the peripherally synapsing interneuron (PSI) and the DLM motor neurons in the thoracic ganglion. gfA complements pas.

Summary (Interactive Fly)

neurotransmitter-gated ion-channels - cholinergic synapse formation and dendritic refinement - site of action of insecticides

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\nAChRα7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry E1JJR2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

nAChRα7-RA

FBtr0074680

NM_206791

4145

560

nAChRα7-RD

FBtr0301834

NM_167645

5522

560

nAChRα7-RE

FBtr0301835

NM_001169324

4214

564

nAChRα7-RF

FBtr0343798

NM_001298507

5607

560

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

nAChRα7-PA

FBpp0089248

63.1

560

5.47

FBpp0291048

63.1

560

5.47

FBpp0291049

63.5

564

5.63

FBpp0310357

63.1

560

5.47

Q9VWI9

NP_001285436

AHN59906

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

560 aa isoforms: nAChRα7-PA, nAChRα7-PD, nAChRα7-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nAChRα7 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nAChRalpha7_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

lamina monopolar neuron L2

(Takemura et al., 2011)

lamina monopolar neuron L4

(Takemura et al., 2011)

transmedullary neuron Tm2

(Takemura et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

horizontal system neuron

• dendrite terminus

(Raghu et al., 2009)

vertical system neuron

• dendrite terminus

(Raghu et al., 2009)

lobula plate | restricted

(Raghu et al., 2009)

adult periesophageal neuropils | restricted

(Raghu et al., 2009)

antennal mechanosensory and motor center | restricted

(Nakayama et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

nAChRalpha7 protein is expressed in the dendritic terminals of the horizontal and vertical system neurons in the lobula plate. It is also expressed in other periesophageal neuropils.

(Raghu et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of acetylcholine-gated channel complex

inferred from physical interaction with FLYBASE:nAChRα5; FB:FBgn0028875,FLYBASE:nAChRα6; FB:FBgn0032151

(Lansdell et al., 2012)

located_in dendrite

inferred from direct assay

(Fayyazuddin et al., 2006)

located_in dendritic spine

inferred from direct assay

(Leiss et al., 2009)

located_in postsynaptic density

inferred from direct assay

(Kremer et al., 2010)

Expression Deduced from Reporters

Reporter: P{mb247-nAChRα7-GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

Kenyon cell of calyx of adult mushroom body

• postsynaptic density

(Christiansen et al., 2011)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\nAChRα7 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nAChRα7

View exonic expression by tissue for Dmel\nAChRα7

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32928/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086778

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086778

Flygut - An atlas of the Drosophila adult midgut

FBgn0086778

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 34 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 25 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nAChRα7

Transgenic constructs containing regulatory region of nAChRα7

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(1)Exel7468

(Ryder, 2004.4.26)

Df(1)JA27

(Thomas and Wyman, 1984)

Gene partially disrupted in

Df(1)lncRNA:lrg-KO

(Cui et al., 2024)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nAChRα7^GD3742

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

viable, with Scer\GAL4^Mef2.PR

nAChRα7^GD3742

viable, with Scer\GAL4^pnr-MD237

nAChRα7^GD3742

Sterility

Allele

fertile

nAChRα7^EY10801

Other Phenotypes

Allele

abnormal behavior | recessive

abnormal jumping | dominant

nAChRα7¹

abnormal neuroanatomy

nAChRα7^unspecified

abnormal neurophysiology

abnormal neurophysiology, with Scer\GAL4^shot-OK307

abnormal neurophysiology (with nAChRα7¹)

abnormal neurophysiology (with nAChRα7^PΔ5)

nAChRα7¹

abnormal neurophysiology (with nAChRα7^PΔEY6)

nAChRα7¹

abnormal neurophysiology | chemical conditional

nAChRα7^PΔEY6

abnormal neurophysiology | dominant

chemical resistant

nAChRα7^KO.dsRed+

chemical resistant, with Scer\GAL4^elav.PU

nAChRα7^GD3742

chemical resistant | larval stage

nAChRα7^ΔD6

decreased efficacy of long-term memory | adult stage, with Scer\GAL4^GMR54H02

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nAChRα7^GD3742

Phenotype manifest in

Allele

dendrite

nAChRα7^unspecified

dorsal longitudinal indirect flight muscle cell, with Scer\GAL4^shot-OK307

giant fiber neuron

giant fiber neuron (with nAChRα7¹)

giant fiber neuron (with nAChRα7^PΔ5)

nAChRα7¹

giant fiber neuron (with nAChRα7^PΔEY6)

nAChRα7¹

indirect flight muscle motor neuron DLMN5

nAChRα7^unspecified

neuron

nAChRα7^PΔEY6

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (27)

Hsap\CHRFAM7A

12 of 14

Yes

Hsap\CHRNA7

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CHRNG

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

Rnor\Chrna7

11 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Glra3

1 of 14

Rnor\Htr3a

1 of 14

Rnor\Htr3b

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Chrna7

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\chrna7

10 of 13

Yes

Xtro\LOC100487782

10 of 13

Yes

Xtro\lman2l

9 of 13

Yes

Xtro\chrna9

2 of 13

Yes

Xtro\chrna10

2 of 13

Yes

Xtro\adal

1 of 13

Xtro\chrna2

1 of 13

Xtro\chrne

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100494266

1 of 13

Xtro\LOC116410385

1 of 13

Yes

Danio rerio (Zebrafish) (35)

Drer\chrna11

12 of 14

Yes

Drer\chrna7a

11 of 14

Yes

Drer\chrna8

11 of 14

Yes

Drer\LOC101882451

11 of 14

Yes

Drer\chrna9a

2 of 14

Yes

Drer\chrna10a

2 of 14

Drer\LOC798522

2 of 14

Yes

Drer\LOC101882637

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100334841

1 of 14

Drer\LOC101884593

1 of 14

Yes

Drer\LOC101885757

1 of 14

Yes

Drer\LOC103909988

1 of 14

Yes

Drer\LOC110439304

1 of 14

Drer\si:ch211-256e16.4

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (64)

Cele\acr-16

11 of 14

Yes

Cele\acr-11

9 of 14

Yes

Cele\acr-9

7 of 14

Yes

Cele\acr-25

7 of 14

Yes

Cele\eat-2

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

Yes

Cele\acr-19

4 of 14

Cele\acr-18

3 of 14

Yes

Cele\lgc-12

3 of 14

Cele\acr-6

2 of 14

Cele\acr-17

2 of 14

Yes

Cele\acr-21

2 of 14

Yes

Cele\lgc-1

2 of 14

Cele\lgc-4

2 of 14

Yes

Cele\lgc-5

2 of 14

Yes

Cele\lgc-6

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Cele\lgc-28

2 of 14

Yes

Cele\lgc-29

2 of 14

Cele\pbo-5

2 of 14

Yes

Cele\pbo-6

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\lgc-30

1 of 14

Cele\lgc-31

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP000962

12 of 12

Yes

6 of 12

5 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP012581

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:nAChRα7. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

11 of 13

11 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Grd

2 of 13

Lcch3

2 of 13

nAChRα2

2 of 13

NtR

2 of 13

pHCl-2

2 of 13

Rdl

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

ort

1 of 13

pHCl-1

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

nAChRα7^PΔEY6

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Hahm et al., 2018)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CHRFAM7A; CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion

12 of 14

609756

CHRNA7; cholinergic receptor nicotinic alpha 7 subunit

12 of 14

118511

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

nAChRα7 - hig

anti tag coimmunoprecipitation, western blot

(Nakayama et al., 2016)

nAChRα7 - nAChRα6

anti tag coimmunoprecipitation, anti tag western blot

(Lansdell and Millar, 2004)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0086778

MIST (protein-protein) - An integrated Molecular Interaction Database

32928

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-62

Cytogenetic map

18C2-18C3

Sequence location

X:19,327,075..19,348,447 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

18C2-18C3

Limits computationally determined from genome sequence between P{EP}CG8051^EP1550&P{EP}EP1300 and P{EP}EP1526&P{EP}Pfrx^EP1150

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

18C3-18C3

(Grauso, 2001.5.26)

Experimentally Determined Recombination Data

Location

1-62

(FlyBase, 2016)

1-61.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

(Thomas and Wyman, 1984)

Notes

1-61.1

Stocks and Reagents

Stocks (35)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24880

nAChRα7¹

24879

nAChRα7^PΔEY6

64147

w^*; P{UAS-nAChRα7.M}2

64148

w^*; P{UAS-nAChRα7.M}3

64146

w^*; P{UAS-nAChRα7.D197A}3

49861

w¹¹¹⁸; P{GMR21D09-GAL4}attP2

64141

w^*; P{UAS-nAChRα7.Y195T}2/CyO

64145

w^*; P{UAS-nAChRα7.D197A}2/CyO

10712

8082R-2

v100756

v11329

w¹¹¹⁸; P{GD3742}v11329

More stocks available...

Genomic Clones (26)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0086778

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0086778

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Nakayama et al., 2023)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Mutations disrupt the synaptic transmission of the giant fibre (GF) - dorso-longitudinal muscle (DLM) pathway.

(Thomas and Wyman, 1984)

gfA¹/Df(1)JA27 is said to be indistinguishable from gfA¹/gfA¹ (Thomas and Wyman, 1984). Physiological effects of gfA¹ and gfA² are ostensibly the same.

Relationship to Other Genes

Source for database merge of

Source for merge of: gfA nAcRα-18C

(Fayyazuddin et al., 2006)

Source for merge of: nAcRα-18C gfA

(Fayyazuddin et al., 2006)

Source for merge of: nAcRα-18C CG8082

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG8082 and CG8109 merged as CG32538 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for identity of nAcRα-18C CG8109 was sequence comparison ( date:020502 ).

(FlyBase, 1996-)

gfA complements pas.

Nomenclature History

Source for database identify of

Source for identity of: nAcRα-18C CG8109

(FlyBase, 1996-)

Source for identity of: nAChRα7 gfA

(FlyBase, 2009-)

Nomenclature comments

Renamed genes encoding nicotinic Acetylcholine Receptors to give systematic nomenclature that better reflects usage in literature (e.g. FBrf0218556, FBrf0183743).

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (44)

Reported As

Symbol Synonym

AcR-Dα7

(Gupta et al., 2016)

CG32538

(Mao et al., 2024, Kondo et al., 2020, Transgenic RNAi Project members, 2017-, Tsubouchi et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

CG8082

CG8109

CT24218

(Littleton and Ganetzky, 2000)

Da7

(Christiansen et al., 2011)

Dalpha7

(Venken et al., 2006)

Dα7

(Anthoney et al., 2023, Giordani et al., 2023, Nakayama et al., 2023, Shao et al., 2022, Baltruschat et al., 2021, Kohrs et al., 2021, Nguyen et al., 2021, Perry et al., 2021, Chodankar et al., 2020, Eadaim et al., 2020, Fendl et al., 2020, Hahm et al., 2018, Hussain et al., 2018, Morris et al., 2018, Hoggard et al., 2017, Velazquez-Ulloa, 2017, Ffrench-Constant et al., 2016, Kidd and Lieber, 2016, Nakayama et al., 2016, Heghinian et al., 2015, Perry et al., 2015, Somers et al., 2015, Nakayama et al., 2014, Wu et al., 2014, Flood et al., 2013, Kuehn and Duch, 2013, Mejia et al., 2013, Zhang et al., 2013, Dupuis et al., 2012, Lansdell et al., 2012, Ping and Tsunoda, 2011, Takemura et al., 2011, Kremer et al., 2010, Mejia et al., 2010, Owald et al., 2010, Fotowat et al., 2009, Leiss et al., 2009, Raghu et al., 2009, Chanut, 2006, Fayyazuddin et al., 2006, Fayyazuddin et al., 2006, Venken, 2006, Sattelle et al., 2005, Lansdell and Millar, 2004, Grauso et al., 2002)

Dα7 nAChR

(Vonhoff et al., 2013)

Dα7-nAChR

(Ping and Tsunoda, 2011)

Dα7nAChRs

(Ryglewski et al., 2017)

gfA

(Li et al., 2018, Pan et al., 2015, Schleich et al., 2014, Mejia et al., 2013, Bellen, 2012.6.6, Japanese National Institute of Genetics, 2012.5.21, Lee and Reinhardt, 2012, Rodriguez et al., 2012, Perkins et al., 2009.8.10, Venken et al., 2009, Fayyazuddin et al., 2006, Lindsley and Zimm, 1992)

gfa

(Tsubouchi et al., 2012)

jpl

nAChR

(Barber et al., 2021, Rodrigues et al., 2021, Flood et al., 2013, Tomizawa et al., 2003, Wolf and Heberlein, 2003, Schafer, 2002)

nAChR-Dα7

(Zhang et al., 2013)

nAChR-gfa

(Ren et al., 2012)

nAChRa7

(Rabah et al., 2025)

nAChRalpha7

(Zhao et al., 2025, Deshpande et al., 2022, Kondo et al., 2020, Rao and Deng, 2019.10.23, Gene Disruption Project members, 2016-)

nAcRalpha-18C

(Crocker et al., 2016)

nAcRalpha18C

(Aradska et al., 2015)

nAcRα-18C

(Younger et al., 2013, Ping and Tsunoda, 2011, Fayyazuddin et al., 2006, Sattelle et al., 2005, FlyBase, 1996-)

nAcRα-7

(Takemura et al., 2011)

nAchRa7

(Gnerer et al., 2015)

nachRalpha7

(Corthals et al., 2023)

nj507

nj520

nj522

nj54

nj75

Name Synonyms

Dalpha7

(Venken, 2006)

Dα7 subunit of the acetylcholine receptor

(Kremer et al., 2010)

Dα7 subunit of the nicotinic acetylcholine receptor

(Kremer et al., 2010)

Shaker cognate L

(Ping and Tsunoda, 2011)

giant fiber A

(Lindsley and Zimm, 1992)

giant fibre A

(Tsubouchi et al., 2012)

jumpless

nicotinic Acetylcholine Receptor α 18C

nicotinic Acetylcholine Receptor α7

non-jumper-507

non-jumper-520

non-jumper-522

non-jumper-54

non-jumper-75

Secondary FlyBase IDs

FBgn0005396
FBgn0001102
FBgn0001290
FBgn0031013
FBgn0052538
FBgn0031014

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32928

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

E1JJR2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

E1JJR2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32928/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0086778

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0086778

FlyMine - An integrated database for Drosophila genomics

FBgn0086778

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32538

MARRVEL_MODEL - MARRVEL (model organism gene)

32928

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0086778

DroID - A comprehensive database of gene and protein interactions.

FBgn0086778

DRSC - Results frm RNAi screens

FBgn0086778

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nAChRalpha7_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0086778

Flygut - An atlas of the Drosophila adult midgut

FBgn0086778

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0086778

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001431

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

32928

References (167)

The following external sites may use different assemblies or annotations than FlyBase.

-0.49

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