FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\nAChRα7D77T.L117Q.I196P.UAS
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General Information
Symbol
Dmel\nAChRα7D77T.L117Q.I196P.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0285440
Feature type
allele
Associated gene
Dmel\nAChRα7
Associated Insertion(s)
Carried in Construct
P{UAS-nAChRα7.D77T.L117Q.I196P}
Also Known As
UAS-Dα7-D77T/L117Q/I196P
Key Links
Transgenic product class
missense_variant
(Mejia et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Mejia et al., 2013)
Mutagen
in vitro construct
(Mejia et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-nAChRα7.D77T.L117Q.I196P}
Cytology
Description

UASt regulatory sequences drive expression of nAChRα7 containing the amino acid replacements D77T, L117Q and I196P.

(Mejia et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
nAChRα7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of gfAD77T.L117Q.I196P.Scer\UAS under the control of Scer\GAL4OK307 results in the response of the dorsal longitudinal muscle to stimulation of the giant fiber having a slightly increased refractory period compared to wild type, but the maximum following frequency is not significantly different from wild type.

      Expression of gfAD77T.L117Q.I196P.Scer\UAS under the control of Scer\GAL4OK307 has no significant effect on the latency of the response of the tergotrochanteral muscle to stimulation of the giant fiber.

      (Mejia et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      nAChRα7D77T.L117Q.I196P.UAS/Scer\GAL4shot-OK307 partially rescues nAChRα7PΔEY6

      (Mejia et al., 2013)
      Comments

      Expression of gfAD77T.L117Q.I196P.Scer\UAS under the control of Scer\GAL4OK307 rescues an electrophysiological response of the dorsal longitudinal muscle (DLM) to stimulation of the giant fiber. However, the refractory period is nearly twice as long as in wild type. In addition, the DLMs are only able to follow 10 pulses given at 100Hz with 67.6% reliability and the maximum frequency to follow 10 stimuli (58 +/- 16 Hz) is reduced by almost half compared to wild type.

      (Mejia et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      gfAD77T.L117Q.I196P.Scer\UAS
      nAChRα7D77T.L117Q.I196P.Scer\UAS
      nAChRα7D77T.L117Q.I196P.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)