FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\srlUAS.cTa
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General Information
Symbol
Dmel\srlUAS.cTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Tiefenbock
FlyBase ID
FBal0285878
Feature type
allele
Associated gene
Dmel\srl
Associated Insertion(s)
Carried in Construct
P{UAS-srl.T}
Also Known As
UAS-Spargel, UAS-Srl
Key Links
Transgenic product class
wild_type
(Tiefenböck et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tiefenböck et al., 2010)
Mutagen
in vitro construct
(Tiefenböck et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-srl.T}
Cytology
Description

UASt regulatory sequences drive expression of the srl-RB isoform including 5' and 3' UTRs.

(Tiefenböck et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
srl
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by park1
      (Ng et al., 2017)
      modeled by Hsap\LRRK2G2019S.UAS.Tag:MYC
      (Ng et al., 2017)
      ameliorates  Huntington's disease
      modeled by Hsap\HTTQ93.ex1.UAS
      (Ruetenik et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of srlScer\UAS.cTa under the control of Scer\GAL4Ddc.PL does not result in any climbing defects or loss of dopaminergic neurons in the PPL1 cluster, nor any morphological defects in the mitochondria of dopaminergic neurons, as compared to controls.

      (Ng et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of srlScer\UAS.cTa under the control of Scer\GAL4how-24B suppresses the climbing defects and mitochondrial defects seen in park1/park1 mutants.

      (Ng et al., 2017)

      Expression of srlScer\UAS.cTa under the control of Scer\GAL4Act.PU suppresses the lethality seen in Baldspot02281 mutants.

      (Senyilmaz et al., 2015)

      Expression of srlScer\UAS.cTa under the control of Scer\GAL4da.G32 partially rescues the developmental delay and bang sensitivity phenotypes of tko25t mutants.

      (Chen et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of srlScer\UAS.cTa partially suppresses the climbing defects and fully suppresses the loss of dopaminergic neurons and the mitochondrial size increase seen in flies expressing Hsap\LRRK2G2019S.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Ddc.PL.

      (Ng et al., 2017)
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      srlScer\UAS.cTa
      srlUAS.cTa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Tiefenbock
      Secondary FlyBase IDs
        References (10)