FB2026_02 , released June 18, 2026
Allele: Mmus\PrkczPKM.hs
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General Information
Symbol
Mmus\PrkczPKM.hs
Species
M. musculus
Name
FlyBase ID
FBal0286129
Feature type
allele
Associated gene
Mmus\Prkcz
Associated Insertion(s)
Carried in Construct
P{hs-MaPKMζ}
Transgenic product class
inframe_deletion
(Drier et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Drier et al., 2002)
Mutagen
in vitro construct
(Drier et al., 2002)
Progenitor genotype
Carried in construct
P{hs-MaPKMζ}
Cytology
Description

An Hsp70 promoter drives expression of a constitutively active form of Mmus\Prkcz ("PKMζ"), which lacks the N-terminal regulatory domain (the mutant protein starts at amino acids 165 of the wild-type protein).

(Drier et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
Mmus\Prkcz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Induction of Mmus\PrkczPKM.hs (using mild heat shock at 32[o]C) strongly enhances 24 hour memory after single-cycle training in an olfactory avoidance conditioning assay. The optimum enhancement occurs when heat-shock induction begins 20 minutes after training ends, and no enhancement is seen if the heat shock occurs before this time, or is delayed until 2 hours after training.

      Induction of Mmus\PrkczPKM.hs (using heat shock 30 minutes after training) enhances 4 day memory after massed training (anesthesia-resistant memory) but has no effect on 4 day memory after spaced training (long term memory) in an olfactory avoidance conditioning assay.

      (Drier et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mmus\PrkczPKM.hs is a suppressor | heat sensitive of abnormal memory phenotype of rshunspecified

      (Drier et al., 2002)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Induction of Mmus\PrkczPKM.hs using heat shock after training suppresses the block in 24 hour memory after massed training (anesthesia-resistant memory) seen in radunspecified males in an olfactory avoidance conditioning assay.

      (Drier et al., 2002)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mmus\PrkczPKM.hs
      Name Synonyms
      Secondary FlyBase IDs
        References (1)