FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sageko
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General Information
Symbol
Dmel\sageko
Species
D. melanogaster
Name
FlyBase ID
FBal0286383
Feature type
allele
Associated gene
Dmel\sage
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Fox et al., 2013)
Mutagen
gene targeting by homologous recombination
(Fox et al., 2013)
Progenitor genotype
Cytology
Description

4kb deletion, which removes the sage gene as wells as a portion of the 3' ends of the neighbouring genes. Expression of the downstream VhaM8.9 gene is reduced by this deletion while expression of the upstream Aats-trp gene is unaffected.

(Fox et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      High levels of apoptotic cell death are seen in mutant salivary glands at stage 14 and 15.

      (Fox et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of BacA\p35Scer\UAS.cUa under the control of Scer\GAL4sage.PV rescues the salivary gland cell death seen in sageko embryos. The rescued salivary glands have lumen irregularities.

      (Fox et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sageko
      (Fox et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)