FB2026_02 , released June 18, 2026
Allele: Dmel\Nek2UAS.ORF
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General Information
Symbol
Dmel\Nek2UAS.ORF
Species
D. melanogaster
Name
FlyBase ID
FBal0286968
Feature type
allele
Associated gene
Dmel\Nek2
Associated Insertion(s)
Carried in Construct
M{UAS-Nek2.ORF}
Key Links
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Schertel et al., 2013)
Mutagen
in vitro construct
(Schertel et al., 2013)
Progenitor genotype
Carried in construct
M{UAS-Nek2.ORF}
Cytology
Description

UASt regulatory sequences drive expression of a full-length Nek2 open reading frame with its native stop codon.

(Schertel et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Nek2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Nek2Scer\UAS.ORF under the control of Scer\GAL4dac-GAL4 leads to a significant inhibition of retinal differentiation and to the overgrowth of the anterior region of the third instar larval eye disc, as compared to controls; expression under the control of Scer\GAL4ey.PU, however, does not lead to any obvious adult eye morphology defects or third instar larval eye disc morphogenetic furrow progression and retinal differentiation impairment, as compared to controls.

      (Martins et al., 2017)

      Expression of Nek2Scer\UAS.ORF under the control of Scer\GAL4Bx-MS1096 results in a severe growth and patterning defects in the adult wing. Ectopic sensory bristles are seen on the wing.

      (Schertel et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of Nek2Scer\UAS.ORF enhances both the third instar larval eye disc morphogenetic furrow progression and retinal differentiation impairment and the adult eye morphology defects induced by the expression of Cdc16GD12028 under the control of Scer\GAL4ey.PU, even leading to a severe expansion of the head case.

      The co-expression of Cdc16GD12028 and Nek2Scer\UAS.ORF under the control of Scer\GAL4dpp.PU leads to a delay in third instar larval eye disc morphogenetic furrow progression, as compared to controls.

      (Martins et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nek2Scer\UAS.ORF
      Nek2UAS.ORF
      Name Synonyms
      Secondary FlyBase IDs
        References (3)