FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SH3PX1HK62b
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General Information
Symbol
Dmel\SH3PX1HK62b
Species
D. melanogaster
Name
FlyBase ID
FBal0287805
Feature type
allele
Associated gene
Dmel\SH3PX1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Knævelsrud et al., 2013)
Mutagen
P-element activity
(Knævelsrud et al., 2013)
Progenitor genotype
P{EPgy2}SH3PX1EY08084
(Knævelsrud et al., 2013)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 1198bp deletion extending from the original insertion site which removes the first exon and start codon of SH3PX1.

(Knævelsrud et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:9,713,777..9,714,974 [-]
Comment:

1198 bp deletion resulting from the imprecise excision of P{EPgy2}SH3PX1EY08084, extends from the insertion site into the SH3PX1 gene.

(Knævelsrud et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  colorectal cancer
      CEA with SH3PX1d1
      (Zhang et al., 2019)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      7 days old SH3PX1d1/SH3PX1HK62b transheterozygotes display a severe increase in the number of mitotic cells (phospho-H3 staining) in the adult midgut, as compared to SH3PX1d1 heterozygous controls.

      (Zhang et al., 2019)

      Autophagic compartments are fewer and smaller in homozygous clones of fat body cells in larvae after starvation compared to those seen in wild-type cells under these conditions.

      (Knævelsrud et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      SH3PX1HK62b
      (Zhang et al., 2024, Zhang et al., 2019, Knævelsrud et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)