FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Aatfnutmeg-21.3
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General Information
Symbol
Dmel\Aatfnutmeg-21.3
Species
D. melanogaster
Name
FlyBase ID
FBal0287850
Feature type
allele
Associated gene
Dmel\Aatf
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jagut et al., 2013)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Egg chambers containing Aatfnutmeg-21.3 mutant germline clones arrest development at stage three of oogenesis. The centrosomes are correctly restricted to one cell in each mutant cyst, but fail to localise to the posterior pole of the oocyte.

      The number of double stranded break foci in Aatfnutmeg-21.3 mutant germline cells is similar to wild type. As in wild type these foci disappear in region three of the germarium.

      (Jagut et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Aatfnutmeg-21.3 has abnormal cell polarity | germline clone phenotype, non-suppressible by mei-41D3

      (Jagut et al., 2013)
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      Aatfnutmeg-21.3 has egg chamber | germline clone phenotype, non-suppressible by mei-41D3

      (Jagut et al., 2013)

      Aatfnutmeg-21.3 has oocyte | germline clone phenotype, non-suppressible by mei-41D3

      (Jagut et al., 2013)

      Aatfnutmeg-21.3 has centrosome | germline clone phenotype, non-suppressible by mei-41D3

      (Jagut et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mei-41D3 is unable to suppress the early oogenesis arrest and oocyte polarity phenotypes seen in Aatfnutmeg-21.3 mutant germline clones.

      (Jagut et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Aatfnutmeg-29.3

      (Jagut et al., 2013)

      Aatfe03057

      (Jagut et al., 2013)
      Rescued by

      Aatfnutmeg-21.3 is rescued by Scer\GAL4VP16.nanos.UTR/AatfUASp.EGFP

      (Jagut et al., 2013)
      Comments

      Expression of AatfScer\UAS.P\T.T:Avic\GFP-EGFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 fully rescues the egg chamber arrest and oocyte polarity defects seen in Aatfnutmeg-21.3 mutant germline clones.

      (Jagut et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      21.3
      (Jagut et al., 2013)
      AATF21.3
      (Jagut et al., 2013)
      Aatfnutmeg-21.3
      Che-121.3
      (Jagut et al., 2013)
      Nutmeg21-3
      (Jagut et al., 2013)
      nutmeg21.3
      (Jagut et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)