FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rlUAS.Tag:NLS(Unk)
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General Information
Symbol
Dmel\rlUAS.Tag:NLS(Unk)
Species
D. melanogaster
Name
FlyBase ID
FBal0288222
Feature type
allele
Associated gene
Dmel\rl
Associated Insertion(s)
Carried in Construct
P{UAS-rl.NLS}
Key Links
Transgenic product class
wild_type
(Chen et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chen et al., 2013)
Mutagen
in vitro construct
(Chen et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-rl.NLS}
Cytology
Description

UAS regulatory sequences drive expression of rl which is tagged at the C-terminal end with a nuclear localization signal.

(Chen et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
rl
Tagged with
Tag:NLS(Unk)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      rlUAS.Tag:NLS(Unk), Scer\GAL4NP1624 is a non-suppressor of male sterile phenotype of LamGD1478, Scer\GAL4NP1624

      (Chen et al., 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of rlScer\UAS.T:Uuuu\nls6 partially rescues the germline stem cell differentiation defect seen in males expressing LamGD1478 under the control of Scer\GAL4tj-NP1624 : spermatocytes and sperm bundles are formed in 45.2% of testes and the increased number of early germ cells is partially reduced in the remaining testes. Fertility is not rescued.

      Expression of rlScer\UAS.T:Uuuu\nls6 under the control of Scer\GAL4tj-NP1624 rescues the defects in germline stem cell differentiation seen in LamD395/Df(2L)cl-h1 males. In 40.6% of testes spermatocytes are formed and the gonads do not accumulate many early germline cells. The mislocalisation of the cyst stem cell nuclei adjacent to the hub and the reduction in number of germline stem cells associated with the hub are also partially rescued.

      (Chen et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      rlScer\UAS.T:Uuuu\nls-Unk
      rlScer\UAS.T:Uuuu\nls6
      rlUAS.Tag:NLS(Unk)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)