FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\LRRK2Y1699C.UAS.Tag:MYC
Open Close
General Information
Symbol
Hsap\LRRK2Y1699C.UAS.Tag:MYC
Species
H. sapiens
Name
FlyBase ID
FBal0288351
Feature type
allele
Associated gene
Hsap\LRRK2
Associated Insertion(s)
Carried in Construct
P{UAS-LRRK2.Y1699C.myc}
Key Links
Transgenic product class
missense_variant
(Ng et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ng et al., 2009)
Mutagen
in vitro construct
(Ng et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-LRRK2.Y1699C.myc}
Cytology
Description

UASt regulates expression of Hsap\LRRK2 containing a Y1699C mutation, tagged with Tag:MYC at the C terminus.

(Ng et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\LRRK2
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Ng et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Ng et al., 2009)
      LRRK2:p.Tyr1699Cys
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: LRRK2_1937
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4elav.PU-mediated expression of Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC does not appear to compromise the overall anatomical integrity of the fly brain up to 60 d after eclosion. Scanning electron microscope analysis reveals no apparent eye abnormalities in Scer\GAL4GMR.PU Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC flies at 20 d after eclosion. Similar observations are made when these flies are aged to 60 d. In 60 day old, but not 1 or 20 day old, flies expressing Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC via Scer\GAL4Ddc.PL, there is significant degeneration of DA neurons in the PPM clusters 1 and 3 (but not PAL, PPM2, PPL1 or PPL2) compared with age-matched normal control flies. 60 day old, but not 20 day old, flies expressing Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC via Scer\GAL4Ddc.PL record dramatically poorer climbing scores compared to controls. Flies expressing Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC via Scer\GAL4Ddc.PL have a reduced lifespan. There is no accelerated loss of DA neurons of rotenone-treated flies expressing Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC via Scer\GAL4Ddc.PL, compared to controls.

      (Ng et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\LRRK2Y1699C.Scer\UAS.T:Hsap\MYC
      Hsap\LRRK2Y1699C.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (2)