FlyBase Allele Report: Hsap\HNRNPA2B1[UAS.cKa]

General Information

Symbol

Hsap\HNRNPA2B1^UAS.cKa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Kim

FlyBase ID

FBal0288447

Feature type

allele

Associated gene

Hsap\HNRNPA2B1

Associated Insertion(s)

Carried in Construct

P{UAS-HNRNPA2B1.K}

Also Known As

hnRNPA2 WT

Key Links

Transgenic product class

wild_type

(Kim et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kim et al., 2013)

Mutagen

in vitro construct

(Kim et al., 2013)

Progenitor genotype

Carried in construct

P{UAS-HNRNPA2B1.K}

Cytology

Description

UASt regulatory sequences drive expression of wild type Hsap\HNRNPA2B1.

(Kim et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\HNRNPA2B1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis

CEA

(Ishiguro et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates spinocerebellar ataxia 31

modeled by Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^W.UAS, TBPH^GD6943

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

modeled by Zzzz\UGGAA^S.UAS, TBPH^GD6943

(Ishiguro et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PS

(Ishiguro et al., 2017)

indirect flight muscle cell, with Scer\GAL4^Mhc.PU

(Kim et al., 2013)

Detailed Description

Statement

Reference

The expression of Hsap\HNRNPA2B1^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PS leads to a mild rough eye phenotype, as compared to controls.

(Ishiguro et al., 2017)

Expression of Hsap\HNRNPA2B1^{D290V.Scer\UAS} driven by Scer\GAL4^Mhc.PW does not result in cytoplasmic inclusions in the indirect flight muscle.

(Li et al., 2016)

Expression of Hsap\HNRNPA2B1^Scer\UAS.cKa in the indirect flight muscles under the control of Scer\GAL4^Mhc.PU leads to mild degeneration affecting the rostral portion of several muscles.

(Kim et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

TBPH^GD6943/Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

TBPH^GD6943/Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PS, TBPH^GD6943, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PS, TBPH^GD6943, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor of lethal phenotype of Scer\GAL4^GMR.PS, TBPH^GD6943, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

TBPH^GD6943/Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of eye | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of eye | adult stage phenotype of Scer\GAL4^GMR.PS, TBPH^GD6943, Zzzz\UGGAA^W.UAS

(Ishiguro et al., 2017)

TBPH^GD6943/Hsap\HNRNPA2B1^UAS.cKa, Scer\GAL4^GMR.PS is a suppressor | partially of eye | adult stage phenotype of Scer\GAL4^GMR.PS, Zzzz\UGGAA^S.UAS

(Ishiguro et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The additional expression of Hsap\HNRNPA2B1^Scer\UAS.cKa leads to partial decreases in the severity of the eye defects either resulting from the Scer\GAL4^GMR.PS-driven expression of Zzzz\UGGAA^W.Scer\UAS alone or the combined expression of Zzzz\UGGAA^W.Scer\UAS and TBPH^GD6943 (i.e. reduced size, loss of pigmentation, defective morphology and ommatidial abnormalities).

The co-expression of Hsap\HNRNPA2B1^Scer\UAS.cKa rescues the lethality resulting from the co-expression of Zzzz\UGGAA^S.Scer\UAS and TBPH^GD6943 under the control of Scer\GAL4^GMR.PS; the rescued adults exhibit significantly less severe eye phenotypes, as compared to individuals only expressing Zzzz\UGGAA^S.Scer\UAS under the control of Scer\GAL4^GMR.PS.

(Ishiguro et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\HNRNPA2B1^Scer\UAS.cKa

Hsap\HNRNPA2B1^UAS.cKa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Kim

Secondary FlyBase IDs

References (5)

Report Sections

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