FB2026_03 , released September 17, 2026
Allele: Dmel\Hrb98DED302V.UAS
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General Information
Symbol
Dmel\Hrb98DED302V.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0288453
Feature type
allele
Associated gene
Dmel\Hrb98DE
Associated Insertion(s)
Carried in Construct
P{UAS-Hrb98DE.D302V}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Kim et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kim et al., 2013)
Mutagen
in vitro construct
(Kim et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Hrb98DE.D302V}
Cytology
Description

UASt regulatory sequences drive expression of a mutant form of Hrb98DE containing the D302V amino acid replacement.

(Kim et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hrb98DE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:28,603,211..28,603,211 [+]
Nucleotide change:

A28603211T

Amino acid change:

D305V | Hrb98DE-PA; D306V | Hrb98DE-PB; D306V | Hrb98DE-PC; D302V | Hrb98DE-PD; D301V | Hrb98DE-PE; D302V | Hrb98DE-PF

Reported amino acid change:

D302V

Comment:

Analogous mutation in human HNRNPA2B1 implicated in inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 2; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.

(Kim et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Kim et al., 2013)

      Analogous mutation in two paralogous human genes (HNRNPA2B1 and HNRNPA1) implicated in sub-types of IBMPFD.

      HNRNPA2B1:p.Asp302Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      HNRNPA2B1:p.As290Val
      Associated human disease model(s)
      External database links
      ClinVar: 65454
      Comments concerning this variant
      HNRNPA1:p.Asp314Val
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      HNRNPA1:p.Asp262Val
      Associated human disease model(s)
      External database links
      ClinVar: 65451
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hrb98DED302V.Scer\UAS
      Hrb98DED302V.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)