FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\rhea15-39
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General Information
Symbol
Dmel\rhea15-39
Species
D. melanogaster
Name
FlyBase ID
FBal0288475
Feature type
allele
Associated gene
Dmel\rhea
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ghabrial et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q2052term.

(Levi et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:8,568,705..8,568,705 [+]
Nucleotide change:

C8568705T

Amino acid change:

Q2052term | rhea-PB; Q2052term | rhea-PC; Q2052term | rhea-PD; Q2052term | rhea-PE; Q2052term | rhea-PF; Q2031term | rhea-PG; Q2052term | rhea-PH

Reported amino acid change:

Q2052term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Levi et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      rhea15-39 mutants exhibit terminal cell pruning with multiple convoluted lumens.

      (Ghabrial et al., 2011)

      rhea15-39 mutants display dorsal closure and germ band retraction defects.

      (Franco-Cea et al., 2010)

      rhea15-39 dorsal branch terminal cell clones in third instar larvae have ~70% fewer terminal branches than wild-type clones. Most of the rhea15-39 clone terminal cell branches contain a single, smooth, air-filled lumen as in wild-type branches. However, in the tips of some branches, the lumen is convoluted or extra lumens are present.

      (Levi et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on the extent of the tracheal luminal phenotype, the following rhea alleles can be ranked from weakest to strongest: rhea15-39 < rhea14-69 < rhea6-66 < rhea13-8.

      (Levi et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      1539
      (Ghabrial et al., 2011)
      rhea15-39
      (Franco-Cea et al., 2010)
      rhea1539
      tendrils15-39
      (Levi et al., 2006, Levi et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0268687
      • FBal0193597
      References (4)