FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Sema2b3'UTR.UAS
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General Information
Symbol
Dmel\Sema2b3'UTR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0288697
Feature type
allele
Associated gene
Dmel\Sema2b
Associated Insertion(s)
Carried in Construct
P{UAS-Sema2b.3'UTR}
Also Known As
UAS-sema-2b
Key Links
Transgenic product class
wild_type
(Joo et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Joo et al., 2013)
Mutagen
in vitro construct
(Joo et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Sema2b.3'UTR}
Cytology
Description

UAS regulatory sequences drive expression of the Sema2b coding region and 3'UTR.

(Joo et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sema2b
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sema-2b3'UTR.Scer\UAS under the control of Scer\GAL4peb-GAL4 restores the dorsolateral/ventromedial axon bundle ratio in Sema-2bf02042 mutants. However, expression at 29[o]C results in differential Sema-2b3'UTR.Scer\UAS expression between the two bundles, with a bias towards the ventromedial trajectory, in some cases almost completely removing the dorsolateral bundle. Sufficiently high levels of Sema-2b can thus force dorsolateral axons to choose the ventromedial trajectory.

      Overexpression of Sema-2b3'UTR.Scer\UAS in pupal axons, under the control of Scer\GAL4peb-GAL4, causes significant Or67d and Or88a mistargeting to the ventral antennal lobe. These mis-targeted axons always project to immediately adjacent regions, with Or67d axons medial to Or88a axons in 89% of cases.

      (Joo et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sema-2b3'UTR.Scer\UAS
      Sema2b3'UTR.Scer\UAS
      Sema2b3'UTR.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)