FB2026_02 , released June 18, 2026
Allele: Dmel\Gr43aUAS.cMa
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General Information
Symbol
Dmel\Gr43aUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Miyamoto
FlyBase ID
FBal0290233
Feature type
allele
Associated gene
Dmel\Gr43a
Associated Insertion(s)
Carried in Construct
P{UAS-Gr43a.M}
Also Known As
UAS-Gr43a
Key Links
Transgenic product class
wild_type
(Miyamoto et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Miyamoto et al., 2012)
Mutagen
in vitro construct
(Miyamoto et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Gr43a.M}
Cytology
Description

UAS regulatory sequences drive expression of Gr43a.

(Miyamoto et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Gr43a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Gr43a-GAL4/Gr43aUAS.cMa rescues Gr43aGAL4

      (Mishra et al., 2013)

      Scer\GAL4Gr43a-GAL4/Gr43aUAS.cMa rescues Gr43aGAL4

      (Miyamoto et al., 2012)
      Partially rescues

      Scer\GAL80ChAT.7.4P, Scer\GAL4Gr43a-GAL4, Gr43aUAS.cMa partially rescues Gr43aGAL4

      (Mishra et al., 2013)
      Comments

      Expression of Gr43aScer\UAS.cMa under the control of Scer\GAL4Gr43a-GAL4 rescues the loss of sugar preference in two-choice preference assays seen in Gr43aGAL4 mutant larvae. Preferences for fructose, glucose, melezitose and sorbitol are all restored.

      Expression of Gr43aScer\UAS.cMa under the control of Scer\GAL4Gr43a-GAL4 (restricted to the brain using Scer\GAL80ChAT.7.4P) rescues the defects in glucose and sorbitol preference in two-choice preference assays seen in Gr43aGAL4 mutant larvae. The preference for fructose is not fully rescued and is still severely reduced.

      (Mishra et al., 2013)

      Expression of Gr43aScer\UAS.cMa under the control of Scer\GAL4Gr43a-GAL4 rescues the reduced Ca[2+] response to fructose which is seen in taste neurons of the foreleg in Gr43aGAL4 homozygotes.

      Expression of Gr43aScer\UAS.cMa under the control of Scer\GAL4Gr43a-GAL4 rescues a preference for 100mM sorbitol over water in a modified capillary feeding assay in Gr43aGAL4 homozygotes. This rescue is still seen in the presence of Scer\GAL80Cha.7.4P (which limits expression to the Scer\GAL4Gr43a-GAL4-expressing neurons in the brain).

      Expression of Gr43aScer\UAS.cMa under the control of Scer\GAL4Gr43a-GAL4 rescues the over-consumption of sucrose and glucose seen in Gr43aGAL4 homozygotes in a modified capillary feeding assay.

      Expression of Gr43aScer\UAS.cMa under the control of Scer\GAL4Gr43a-GAL4 in the presence of Scer\GAL80Cha.7.4P rescues the over-consumption of a sorbitol and sucralose solution seen in Gr43aGAL4 homozygotes in a modified capillary feeding assay.

      (Miyamoto et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Gr43aScer\UAS.cMa
      Gr43aUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Miyamoto
      Secondary FlyBase IDs
        References (4)