FB2026_02 , released June 18, 2026
Allele: Mmus\PrnpM205S.M212S.UAS
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General Information
Symbol
Mmus\PrnpM205S.M212S.UAS
Species
M. musculus
Name
FlyBase ID
FBal0290473
Feature type
allele
Associated gene
Mmus\Prnp
Associated Insertion(s)
Carried in Construct
P{UAS-Prp.M205S.M212S}
Transgenic product class
missense_variant
(Sanchez-Garcia et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Sanchez-Garcia et al., 2013)
Mutagen
in vitro construct
(Sanchez-Garcia et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Prp.M205S.M212S}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of Mmus\Prnp which contains the amino acid replacements M205S and M212S.

(Sanchez-Garcia et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Prnp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Mmus\PrnpM205S.M212S.Scer\UAS under the control of Scer\GAL4da.G32 have similar survival curves to control flies.

      Adults expressing Mmus\PrnpM205S.M212S.Scer\UAS under the control of Scer\GAL4BG380 show similar climbing ability to control flies.

      Young flies expressing Mmus\PrnpM205S.M212S.Scer\UAS under the control of Scer\GAL4ey-OK107 have thinner mushroom body dorsal projections than normal that lack the terminal caps. This phenotype does not change significantly as the flies age.

      Flies co-expressing both Mmus\PrnpWT.Scer\UAS and Mmus\PrnpM205S.M212S.Scer\UAS under the control of Scer\GAL4ey-OK107 show a strong developmental defect in the mushroom body (seen in young adults) and show a stronger mushroom body degenerative phenotype than seen in flies expressing Mmus\PrnpWT.Scer\UAS alone.

      (Sanchez-Garcia et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Mmus\PrnpM205S.M212S.Scer\UAS
      Mmus\PrnpM205S.M212S.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)