FB2026_02 , released June 18, 2026
Allele: Dmel\ManfΔRSEL.UAS
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General Information
Symbol
Dmel\ManfΔRSEL.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0291167
Feature type
allele
Associated gene
Dmel\Manf
Associated Insertion(s)
Carried in Construct
P{UAS-Manf.ΔRSEL}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lindström et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Manf.ΔRSEL}
Cytology
Description

UAS regulates expression of Manf lacking the C-terminal RSEL motif (a putative ER retention signal).

(Lindström et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Manf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4da.G32/ManfΔRSEL.UAS rescues ManfΔ96

      (Lindström et al., 2013)
      Partially rescues

      ManfΔRSEL.UAS/Scer\GAL469B partially rescues ManfΔ96

      (Lindström et al., 2013)
      Comments

      ManfΔRSEL.Scer\UAS expression driven by Scer\GAL4da.G32 rescues the early larval lethality of ManfΔ96 mutants to adulthood, and normalizes ManfΔ96 larval dopamine to wild type levels.

      ManfΔRSEL.Scer\UAS expression driven by Scer\GAL469B only partially rescues the early larval lethality of ManfΔ96 mutants.

      (Lindström et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ManfΔRSEL.Scer\UAS
      ManfΔRSEL.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)