FlyBase Allele Report: Dmel\HUWE1[B]

General Information

Symbol

Dmel\HUWE1^B

Species

D. melanogaster

Name

FlyBase ID

FBal0291283

Feature type

allele

Associated gene

Dmel\HUWE1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Yamamoto et al., 2013-)

Progenitor genotype

Cytology

Description

Amino acid replacement: T1107I.

(Yamamoto et al., 2013-)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:15,718,113..15,718,113 [+]

Nucleotide change:

C15718113T

Amino acid change:

Reported amino acid change:

T1107I

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Haelterman et al., 2014, Yamamoto et al., 2013-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | dominant | female | larval stage

(Yanku et al., 2018)

lethal

(Yanku et al., 2018)

Phenotype Manifest In

embryonic/larval salivary gland | female | larval stage

(Yanku et al., 2018)

Detailed Description

Statement

Reference

HUWE1^B heterozygous females show smaller larval salivary glands than controls.

(Yanku et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

HUWE1^B has abnormal size | dominant | female | larval stage phenotype, suppressible by grnd^GD12580/Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

HUWE1^B has abnormal size | dominant | female | larval stage phenotype, suppressible by Traf6^GD7146/Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

HUWE1^B has abnormal size | dominant | female | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/Traf6^KK107947

(Yanku et al., 2018)

HUWE1^B has abnormal size | dominant | female | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/Tab2^KK105926

(Yanku et al., 2018)

NOT Enhancer of

Statement

Reference

HUWE1^B is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

HUWE1^B is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Phenotype Manifest In

Suppressed by

Statement

Reference

HUWE1^B has embryonic/larval salivary gland | female | larval stage phenotype, suppressible by grnd^GD12580/Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

HUWE1^B has embryonic/larval salivary gland | female | larval stage phenotype, suppressible by Traf6^GD7146/Scer\GAL4^ptc-559.1

(Yanku et al., 2018)

HUWE1^B has embryonic/larval salivary gland | female | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/Traf6^KK107947

(Yanku et al., 2018)

HUWE1^B has embryonic/larval salivary gland | female | larval stage phenotype, suppressible by Scer\GAL4^ptc-559.1/Tab2^KK105926

(Yanku et al., 2018)

NOT Enhancer of

Statement

Reference

HUWE1^B is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

HUWE1^B is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Rescued by: Dp(1;3)DC304.

(Yamamoto et al., 2013-)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

52343

y¹ w^* HUWE1^B P{neoFRT}19A/FM7c, P{GAL4-Kr.C}DC1, P{UAS-GFP.S65T}DC5, sn⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG8184^B

(Yamamoto et al., 2013-)

HUWE1^B

(Cheramangalam et al., 2023)

dHUWE1^p

(Yanku et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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