FB2026_02 , released June 18, 2026
Allele: Dmel\AblK417N.UAS.GFP
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General Information
Symbol
Dmel\AblK417N.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0291738
Feature type
allele
Associated gene
Dmel\Abl
Associated Insertion(s)
Carried in Construct
M{10xUAS-Abl.K417N.GFP}
Key Links
Transgenic product class
missense_variant
(O'Donnell and Bashaw, 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(O'Donnell and Bashaw, 2013)
Mutagen
in vitro construct
(O'Donnell and Bashaw, 2013)
Progenitor genotype
Carried in construct
M{10xUAS-Abl.K417N.GFP}
Cytology
Description

A 10xUAS cassette is used to drive expression of a mutated Abl coding sequence (carries a K417N amino acid substitution) tagged at the C-terminal end with GFP.

(O'Donnell and Bashaw, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Abl
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4eg-Mz360, Abl2, AblK417N.UAS.GFP, Abl[+] is a non-enhancer of larval EW neuron phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)

      Scer\GAL4eg-Mz360, Abl2, AblK417N.UAS.GFP, Abl[+] is a non-enhancer of symmetrical commissure phenotype of fra6/fra3

      (O'Donnell and Bashaw, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      AblK417N.UAS.GFP/Scer\GAL4exex-Gal4 fails to rescue Abl2

      (O'Donnell and Bashaw, 2013)
      Comments

      Expression of AblK417N.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4exex-Gal4 fails to rescue the ISNb motor axon defects found in Abl2 mutants.

      (O'Donnell and Bashaw, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AblK417N.Scer\UAS.T:Avic\GFP
      AblK417N.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)