FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AblΔFABD.UAS.GFP
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General Information
Symbol
Dmel\AblΔFABD.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0291743
Feature type
allele
Associated gene
Dmel\Abl
Associated Insertion(s)
Carried in Construct
M{10xUAS-Abl.ΔFABD.GFP}
Key Links
Transgenic product class
inframe_deletion
(O'Donnell and Bashaw, 2013)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(O'Donnell and Bashaw, 2013)
Mutagen
in vitro construct
(O'Donnell and Bashaw, 2013)
Progenitor genotype
Carried in construct
M{10xUAS-Abl.ΔFABD.GFP}
Cytology
Description

A 10xUAS cassette is used to drive expression of Abl coding sequences where the highly-conserved FABD motif has been deleted. The coding sequence is tagged with GFP.

(O'Donnell and Bashaw, 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Abl
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-neural expression of AblΔFABD.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4elav.PLu results in a partially penetrant bypass phenotype. This bypass phenotype occurs when ISNb axons fail to defasciculate, and instead continue to grow dorsally past their muscle targets.

      (O'Donnell and Bashaw, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4ap-md544/AblΔFABD.UAS.GFP is a non-enhancer of abnormal neuroanatomy phenotype of sli2

      (O'Donnell and Bashaw, 2013)
      Phenotype Manifest In
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of AblΔFABD.Scer\UAS.T:Avic\GFP in EW neurons, under the control of Scer\GAL4eg-Mz360 fails to rescue EW midline-crossing defects in Abl2 neurons expressing fraΔC.Scer\UAS.T:Ivir\HA1.

      Expression of AblΔFABD.Scer\UAS.T:Avic\GFP in ap neurons, under the control of Scer\GAL4ap-md544 does not enhance the axon crossing defects found in sli2/+ mutant embryos.

      (O'Donnell and Bashaw, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      AblΔFABD.UAS.GFP/Scer\GAL4exex-Gal4 rescues Abl2

      (O'Donnell and Bashaw, 2013)
      Comments

      Expression of AblΔFABD.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4exex-Gal4 rescues the ISNb motor axon defects found in Abl2 mutants.

      (O'Donnell and Bashaw, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AblΔFABD.Scer\UAS.T:Avic\GFP
      AblΔFABD.UAS.GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)