FlyBase Allele Report: Dmel\α-Cat::shg[Δβ.UASp]

General Information

Symbol

Dmel\α-Cat::shg^Δβ.UASp

Species

D. melanogaster

Name

FlyBase ID

FBal0291805

Feature type

allele

Associated gene

α-Cat::shg

Associated Insertion(s)

Carried in Construct

P{UASp-α-Cat::shg.shgΔβ}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Pacquelet and Rorth, 2005)

Progenitor genotype

Carried in construct

P{UASp-α-Cat::shg.shgΔβ}

Cytology

Description

Full-length α-Cat coding sequences are fused to shg coding sequences where the COOH-terminal domain is deleted. Expression is driven through UASp regulatory sequences.

(Pacquelet and Rorth, 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

α-Cat::shg

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

α-Cat::shg^Δβ.UASp, Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}, shg^R69 has abnormal cell migration | somatic clone phenotype, non-enhanceable by p120ctn^RNAi.700.UAS, Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}

(Pacquelet and Rorth, 2005)

Suppressor of

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^Δβ.UASp is a suppressor of abnormal cell migration | somatic clone phenotype of shg^R69

(Pacquelet and Rorth, 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^Δβ.UASp is a suppressor of border follicle cell | somatic clone phenotype of shg^R69

(Pacquelet and Rorth, 2005)

Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^Δβ.UASp is a suppressor of epithelial cell | somatic clone phenotype of shg^R69

(Pacquelet and Rorth, 2005)

Scer\GAL4^{FRT.Rnor\Cd2.αTub84B}/α-Cat::shg^Δβ.UASp is a suppressor of egg chamber | somatic clone phenotype of shg^R69

(Pacquelet and Rorth, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of shg::α-Cat^{Δβ.Scer\UAS} in follicle cells using the MARCM system and Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B} suppresses the follicle cell sorting, loss of epithelial integrity and oocyte mispositioning phenotypes seen in shg^R69/+ mutant follicle cell clones. In border cells, shg::α-Cat^{Δβ.Scer\UAS} expression partially rescues shg migration defects.

Knockdown of p120ctn through expression of p120ctn^{dsRNA.700.Scer\UAS} in shg::α-Cat^{Δβ.Scer\UAS} mutant border cells, under the control of Scer\GAL4^{Scer\FRT.Rnor\CD2.αTub84B}, does not increase the migration defects observed in shg::α-Cat^{Δβ.Scer\UAS} shg^R69/+ mutant cells.

(Pacquelet and Rorth, 2005)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

shg::α-Cat^{Δβ.Scer\UAS.P\T}

shg::α-Cat^{Δβ.Scer\UAS}

α-Cat::shg^{Δβ.Scer\UAS.P\T}

α-Cat::shg^Δβ.UASp

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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