FlyBase Allele Report: Dmel\Nos[HMC03076]

General Information

Symbol

Dmel\Nos^HMC03076

Species

D. melanogaster

Name

FlyBase ID

FBal0292288

Feature type

allele

Associated gene

Dmel\Nos

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03076}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03076}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03076

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of epilepsy

CEA

(Giachello et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal circadian rhythm | adult stage, with Scer\GAL4^repo

(Kozlov et al., 2020)

abnormal neuroanatomy | P-stage, with Scer\GAL4^elav-C155

(Rabinovich et al., 2016)

abnormal neuroanatomy | P-stage, with Scer\GAL4^ey-OK107

(Rabinovich et al., 2016)

abnormal neuroanatomy | P-stage, with Scer\GAL4^GMR71G10

(Rabinovich et al., 2016)

Phenotype Manifest In

adult mushroom body gamma-lobe | P-stage, with Scer\GAL4^elav-C155

(Rabinovich et al., 2016)

adult mushroom body gamma-lobe | P-stage, with Scer\GAL4^ey-OK107

(Rabinovich et al., 2016)

adult mushroom body gamma-lobe | P-stage, with Scer\GAL4^GMR71G10

(Rabinovich et al., 2016)

axon | P-stage, with Scer\GAL4^elav-C155

(Rabinovich et al., 2016)

axon | P-stage, with Scer\GAL4^ey-OK107

(Rabinovich et al., 2016)

axon | P-stage, with Scer\GAL4^GMR71G10

(Rabinovich et al., 2016)

Detailed Description

Statement

Reference

Expression of Nos^HMC03076 under the control of Scer\GAL4^elav-C155 or Scer\GAL4^ey-OK107, but not Scer\GAL4^repo.PU, leads to a pruning defect and a significant increase in axonal regrowth of mushroom body gamma neurons in P-stage brains both in vivo or cultured ex vivo, as compared to wild type.

Expression of Nos^HMC03076 under the control of Scer\GAL4^GMR71G10 results in a significant pruning defect of axons in the mushroom body gamma-lobe, as compared to controls.

(Rabinovich et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions