FlyBase Allele Report: Dmel\MBD-like[HMS02825]

General Information

Symbol

Dmel\MBD-like^HMS02825

Species

D. melanogaster

Name

FlyBase ID

FBal0293463

Feature type

allele

Associated gene

Dmel\MBD-like

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02825}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02825}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02825

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell adhesion | oogenesis, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

Phenotype Manifest In

border follicle cell, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

chromosome | adult stage | female, with Scer\GAL4^{VP16.mat.αTub67C}

(Nikalayevich and Ohkura, 2015)

oocyte, with Scer\GAL4^{VP16.mat.αTub67C}

(Nikalayevich and Ohkura, 2015)

Detailed Description

Statement

Reference

The expression of MBD-like^HMS02825 under the control of Scer\GAL4^slbo.2.6 leads to a prevalent border cell cluster disassociation phenotype, as well as border cell migration delay in some egg chamber.

(Raza et al., 2019)

Expression of MBD-like^HMS02825 under the control of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} results in significantly increased frequency of undercondensed chromosomes in mature oocytes compared to controls.

(Nikalayevich and Ohkura, 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions