FlyBase Allele Report: Dmel\ry[HMS02827]

General Information

Symbol

Dmel\ry^HMS02827

Species

D. melanogaster

Name

FlyBase ID

FBal0293465

Feature type

allele

Associated gene

Dmel\ry

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02827}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02827}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02827

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of xanthinuria

CEA

(Yin et al., 2017)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of xanthinuria

is ameliorated by Zip71B^GD2461

(Yin et al., 2017)

is ameliorated by ZnT35C^KK112697

(Yin et al., 2017)

is NOT ameliorated by ZnT63C^KK102261

(Yin et al., 2017)

is NOT ameliorated by ZnT41F^KK111282

(Yin et al., 2017)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cUa

(Yadav et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval Malpighian tubule | third instar larval stage, with Scer\GAL4^NP1093

(Yin et al., 2017)

Detailed Description

Statement

Reference

The expression of ry^HMS02827 under the control of Scer\GAL4^{CG10962-NP1093} induces the formation of Malpighian tubule stones in third instar larvae, as compared to controls.

(Yin et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^NP1093, ry^HMS02827 has embryonic/larval Malpighian tubule | third instar larval stage phenotype, suppressible by Scer\GAL4^NP1093/Zip71B^GD2461

(Yin et al., 2017)

Scer\GAL4^NP1093, ry^HMS02827 has embryonic/larval Malpighian tubule | third instar larval stage phenotype, suppressible by Scer\GAL4^NP1093/ZnT35C^KK112697

(Yin et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^NP1093, ry^HMS02827 has embryonic/larval Malpighian tubule | third instar larval stage phenotype, non-suppressible by Scer\GAL4^NP1093/ZnT63C^KK102261

(Yin et al., 2017)

Scer\GAL4^NP1093, ry^HMS02827 has embryonic/larval Malpighian tubule | third instar larval stage phenotype, non-suppressible by Scer\GAL4^NP1093/ZnT41F^KK111282

(Yin et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of Malpighian tubule stones in third instar larvae induced by the expression of ry^HMS02827 under the control of Scer\GAL4^{CG10962-NP1093} is suppressed by the co-expression of Zip71B^GD2461 or ZnT35C^KK112697, but not of ZnT63C^KK102261 or ZnT41F^KK111282.

(Yin et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

44106