FlyBase Allele Report: Dmel\ZnT35C[KK112697]

General Information

Symbol

Dmel\ZnT35C^KK112697

Species

D. melanogaster

Name

FlyBase ID

FBal0238332

Feature type

allele

Associated gene

Dmel\ZnT35C

Associated Insertion(s)

Carried in Construct

P{KK112697}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK112697}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK112697

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Friedreich ataxia 1

modeled by fh^RNAi.UAS.cAa

(Soriano et al., 2016)

ameliorates xanthinuria

modeled by ry^HMS02827

(Yin et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | spermatogenesis, with Scer\GAL4^C587

(He et al., 2025)

chemical sensitive, with Scer\GAL4^NP1093

(Yin et al., 2017)

chemical sensitive, with Scer\GAL4^NP3084

(Yin et al., 2017)

decreased size | spermatogenesis, with Scer\GAL4^C587

(He et al., 2025)

some die during embryonic stage, with Scer\GAL4^C587

(He et al., 2025)

Phenotype Manifest In

cyst cell of testis | increased number, with Scer\GAL4^C587

(He et al., 2025)

cyst progenitor cell | increased number, with Scer\GAL4^C587

(He et al., 2025)

hub cell | increased number, with Scer\GAL4^C587

(He et al., 2025)

male germline stem cell | decreased number, with Scer\GAL4^C587

(He et al., 2025)

primary gonial cell | increased number, with Scer\GAL4^C587

(He et al., 2025)

spermatozoon | decreased number, with Scer\GAL4^C587

(He et al., 2025)

testis, with Scer\GAL4^C587

(He et al., 2025)

Detailed Description

Statement

Reference

The expression of ZnT35C^KK112697 under the control of either Scer\GAL4^{CG10962-NP1093} or Scer\GAL4^NP3084 does not have a significant effect on the eclosion rate reared under normal diet, but these flies exhibit significantly decreased eclosion rates when fed with zinc (but not copper, iron, or EDTA) supplemented food, as compared to control flies.

(Yin et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/ZnT35C^KK112697 is a suppressor | partially of short lived phenotype of ry^GD8894

(Chi et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

ZnT35C^KK112697/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a non-suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^NP1093/ZnT35C^KK112697 is a suppressor of embryonic/larval Malpighian tubule | third instar larval stage phenotype of Scer\GAL4^NP1093, ry^HMS02827

(Yin et al., 2017)

Scer\GAL4^da.PU/ZnT35C^KK112697 is a suppressor of Malpighian tubule phenotype of Scer\GAL4^da.PU, ry^GD8894

(Chi et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

ZnT35C^KK112697/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

ZnT35C^KK112697/Scer\GAL4^GMR.long is a non-suppressor | partially of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of Malpighian tubule stones in third instar larvae induced by the expression of ry^HMS02827 under the control of Scer\GAL4^{CG10962-NP1093} is not suppressed by the co-expression of ZnT35C^KK112697.

(Yin et al., 2017)

Expression of ZnT35C^KK112697 suppresses the malpighian tubule concretions seen when ry^GD8894 is expressed under the control of Scer\GAL4^da.PU. The reduced lifespan is also partially suppressed.

Co-expression of ZnT35C^KK112697 results in an increase in whole fly zinc levels compared to flies expressing ry^GD8894 under the control of Scer\GAL4^da.PU. The levels of other metals remain unchanged.

(Chi et al., 2015)

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^Scer\UAS.cDa under the control of Scer\GAL4^GMR.long do not change upon co-expression of ZnT35C^KK112697 RNAi.

The adult eye phenotype seen upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long can be partially modified by co-expression of ZnT35C^KK112697 RNAi: the morphological defects are unchanged but the pigmentation loss is mildly ameliorated.

The morphological and pigmentation defects in the adult eye seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long are strongly ameliorated by co-expression of ZnT35C^KK112697.

(Dechen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103263

P{KK112697}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ZnT35C^KK112697

ZnT35C^shRNA

(Soriano et al., 2016)

dZnT35C^RNAi

(Dechen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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