FlyBase Allele Report: Dmel\Vha68-1[HMS02962]

General Information

Symbol

Dmel\Vha68-1^HMS02962

Species

D. melanogaster

Name

FlyBase ID

FBal0293536

Feature type

allele

Associated gene

Dmel\Vha68-1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02962}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02962}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02962

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Wang et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

(Wang et al., 2021)

Phenotype Manifest In

Detailed Description

Statement

Reference

Th expression of Vha68-1^HMS02962 under the control of Scer\GAL4^elav-C155 leads to a progressive decrease in adult climbing activity.

(Wang et al., 2021)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Vha68-1^HMS02962, Scer\GAL4^GMR.PF is an enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^GMR.PF

(Wang et al., 2021)

Vha68-1^HMS02962, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Wang et al., 2021)

Vha68-1^HMS02962, Scer\GAL4^elav-C155 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Wang et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Vha68-1^HMS02962, Scer\GAL4^GMR.PF is an enhancer of adult brain phenotype of Hsap\MAPT^UAS.cSa, Scer\GAL4^GMR.PF

(Wang et al., 2021)

Vha68-1^HMS02962, Scer\GAL4^elav-C155 is an enhancer of adult brain phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Wang et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

50726

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02962}attP2

NIG-Fly

HMS02962

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02962}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Vha68-1^HMS02962

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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