FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ced-12EDE.UAS.EYFP
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General Information
Symbol
Dmel\Ced-12EDE.UAS.EYFP
Species
D. melanogaster
Name
FlyBase ID
FBal0293756
Feature type
allele
Associated gene
Dmel\Ced-12
Associated Insertion(s)
Carried in Construct
P{UAS-Ced-12.EDE.YFP}
Key Links
Transgenic product class
missense_variant
(Liu et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Liu et al., 2013)
Mutagen
in vitro construct
(Liu et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Ced-12.EDE.YFP}
Cytology
Description

UASt regulates expression of full-length Ced-12 containing L194E, I196D and L197E substitutions in the EID region, thus creating an 'activated' version, tagged at the C-terminus with EYFP.

(Liu et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Ced-12
Tagged with
EYFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Ced-12EDE.Scer\UAS.T:Avic\GFP-EYFP via Scer\GAL4Mef2.PR results in 70% of L3 larvae having at least a few detached muscle fibers.

      (Liu et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Ced-12EDE.Scer\UAS.T:Avic\GFP-EYFP via Scer\GAL4Mef2.PR partially rescues the msk4 embryonic muscle detachment phenotype.

      (Liu et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ced-12EDE.Scer\UAS.T:Avic\GFP-EYFP
      Ced-12EDE.UAS.EYFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)