FlyBase Allele Report: Dmel\ft[ΔD.Tag:V5]

General Information

Symbol

Dmel\ft^ΔD.Tag:V5

Species

D. melanogaster

Name

FlyBase ID

FBal0294030

Feature type

allele

Associated gene

Dmel\ft

Associated Insertion(s)

Carried in Construct

P{ft.ΔD.V5}

Key Links

Transgenic product class

inframe_deletion

(Pan et al., 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Pan et al., 2013)

Mutagen

in vitro construct

(Pan et al., 2013)

Progenitor genotype

ft^Tag:V5

(Pan et al., 2013)

Carried in construct

P{ft.ΔD.V5}

Cytology

Description

One of six regions of sequence similarity with Hsap\FAT4 been deleted from ft in ft^Tag:V5.

(Pan et al., 2013)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

Tagged with

Tag:V5

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with ft⁸/ft^G-rv

(Bosch et al., 2014)

Phenotype Manifest In

wing, with ft⁸/ft^G-rv

(Bosch et al., 2014)

Detailed Description

Statement

Reference

ft^G-rv/ft⁸; ft^ΔD.T:SV5\V5 wings are slightly overgrown, rounder and have decreased spacing between the crossveins compared to controls.

(Bosch et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of one copy of ft::Hsap\FAT4^T:SV5\V5 fails to suppress the wing overgrowth phenotypes seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔD.T:SV5\V5.

(Pan et al., 2013)

Complementation and Rescue Data

Partially rescues

ft^ΔD.Tag:V5 partially rescues ft⁸/ft^G-rv

(Bosch et al., 2014)

ft^ΔD.Tag:V5 partially rescues ft⁸/ft^G-rv

(Pan et al., 2013)

ft^ΔD.Tag:V5/ft^ΔF.Tag:V5 partially rescues ft⁸/ft^G-rv

(Pan et al., 2013)

Comments

Expression of ft^ΔD.T:SV5\V5 rescues the lethality associated with ft⁸/ft^G-rv. However the wings of the rescued flies are 29% larger than normal and the distance between the anterior and posterior crossveins in 73% of wild type. Only a negligible wing hair planar cell polarity phenotype is seen. The abdominal hair polarity phenotype is fully rescued. The intercellular ridges continue to run from anterior to posterior as in the ft⁸/ft^G-rv mutant posterior wings, rather than proximally to distal, as is seen in wild type.

Expression of one copy of ft^ΔF.T:SV5\V5 partially suppresses the wing overgrowth phenotype seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔD.T:SV5\V5.

Expression of one copy of ft^ΔD.T:SV5\V5 partially suppresses the wing crossvein spacing and hair polarity phenotypes seen in ft⁸/ft^G-rv mutant flies expressing one copy of ft^ΔF.T:SV5\V5.

(Pan et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ft^ΔD.T:SV5\V5

ft^ΔD.Tag:V5

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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