FlyBase Allele Report: Dmel\udd[null]

General Information

Symbol

Dmel\udd^null

Species

D. melanogaster

Name

FlyBase ID

FBal0294171

Feature type

allele

Associated gene

Dmel\udd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zhang et al., 2014)

Mutagen

FLPase

(Zhang et al., 2014)

Progenitor genotype

P{XP}d08197

(Zhang et al., 2014)

PBac{WH}Asap^f00102

(Zhang et al., 2014)

Caused by aberration

Df(2R)udd^null

Cytology

Description

FRT/FLP mediated recombination of PBac{WH}Asap^f00102 and P{XP}d08197 has resulted in almost complete removal of udd and the 3' end of Asap.

(Zhang et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:8,106,386..8,114,491 [+]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in almost complete removal of udd and the 3' end of Asap.

(Zhang et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | germline clone | progressive

(Zhang et al., 2014)

decreased cell number | germline clone | progressive (with udd¹)

(Zhang et al., 2014)

decreased occurrence of cell division | germline clone | progressive (with udd¹)

(Zhang et al., 2014)

decreased size | adult stage (with udd¹)

(Fefelova et al., 2022)

decreased size | adult stage (with udd^0683-G4)

(Fefelova et al., 2022)

increased cell death | oogenesis (with udd^0683-G4)

(Fefelova et al., 2022)

lethal

(Fefelova et al., 2022)

lethal - all die during embryonic stage

(Zhang et al., 2014)

sterile (with udd¹)

(Fefelova et al., 2022)

sterile (with udd^0683-G4)

(Fefelova et al., 2022)

viable (with udd¹)

(Fefelova et al., 2022)

viable (with udd^0683-G4)

(Fefelova et al., 2022)

Phenotype Manifest In

egg chamber (with udd¹)

(Fefelova et al., 2022)

egg chamber (with udd^0683-G4)

(Fefelova et al., 2022)

female germline stem cell | germline clone

(Zhang et al., 2014)

female germline stem cell | germline clone (with udd¹)

(Zhang et al., 2014)

nucleolus | oogenesis (with udd^0683-G4)

(Fefelova et al., 2022)

nurse cell (with udd^0683-G4)

(Fefelova et al., 2022)

ovary (with udd¹)

(Fefelova et al., 2022)

ovary (with udd^0683-G4)

(Fefelova et al., 2022)

testis (with udd¹)

(Fefelova et al., 2022)

testis (with udd^0683-G4)

(Fefelova et al., 2022)

Detailed Description

Statement

Reference

udd¹/udd^null and udd^0683-G4/udd^null ovaries are small. udd¹/udd^null ovaries contain egg chambers only up to stages 4-5 of oogenesis. udd^0683-G4/udd^null ovaries contain egg chambers up to stages 11 of oogenesis, which show apoptotic chromatin condensation; nucleoli in stage 7 nurse cells are less branched.

(Fefelova et al., 2022)

Over time udd^null mutant germline stem cell clones induced in female flies become less proliferative and are eventually lost from the cap cell niche.

Over time udd^null/udd¹ mutant germline stem cell clones induced in female flies become less proliferative and are eventually lost from the cap cell niche.

(Zhang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

udd^null

(Fefelova et al., 2022, Zhang et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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