FB2026_02 , released June 18, 2026
Allele: Dmel\CrzR01
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General Information
Symbol
Dmel\CrzR01
Species
D. melanogaster
Name
FlyBase ID
FBal0294966
Feature type
allele
Associated gene
Dmel\CrzR
Associated Insertion(s)
Mi{ET1}CrzR01
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Sha et al., 2014)
Mutagen
minos activity
(Sha et al., 2014)
Progenitor genotype
CrzRMB00838
(Sha et al., 2014)
Associated Insertion(s)
Mi{ET1}CrzR01
Cytology
Description

Imprecise excision of the Mi{ET1} element in Mi{ET1}CrzRMB00838 has resulted in an 8kb deletion that includes exons 2-5 of CrzR. A footprint of Scer\GAL4 coding region and flanking sequence from the Mi{ET1} element is found at the original insertion site.

(Sha et al., 2014)
Allele components
Component
Use(s)
Inserted element
Mi{ET1}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous CrzR01 mutant flies are viable, fertile and have no discernible morphological or developmental aberrations. Circadian locomotor rhythms are indistinguishable from wild type.

      Homozygous CrzR01 mutant flies show a significantly delayed recovery from ethanol-induced sedation compared to controls. Recovery from ethyl ether-induced sedation is unaffected. Acetaldehyde levels are up to 100% higher than in controls 45 minutes after ethanol exposure. Whole cell and mitochondrial ALDH activity are both reduced. Mitochondrial succinate dehydrogenase activity is similar between control and mutants.

      Homozygous CrzR01 mutant flies are more resistant to acetaldehyde-mediated intoxication than controls. Increased ADH activity is seen.

      CrzR01/Df(3L)BSC380 mutant flies show a significantly delayed recovery from ethanol-induced sedation compared to controls. Acetaldehyde levels are up to 100% higher than in controls 45 minutes after ethanol exposure. Increased ADH activity is seen.

      (Sha et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CrzR01
      (Marini-Davis et al., 2025, Imura et al., 2020, Sha et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)