FlyBase Allele Report: Dmel\gsb-n[del]

General Information

Symbol

Dmel\gsb-n^del

Species

D. melanogaster

Name

FlyBase ID

FBal0295035

Feature type

allele

Associated gene

Dmel\gsb-n

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

FLPase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(He and Noll, 2013)

Mutagen

FLPase

(He and Noll, 2013)

Progenitor genotype

P{XP}gsb-n^d07597

(He and Noll, 2013)

PBac{WH}gsb-n^f06670

(He and Noll, 2013)

Cytology

Description

Scer\FRT-mediated recombination between the two progenitor insertions (PBac{WH}gsb-n^f06670 and P{XP}gsb-n^d07597) has resulted in a deletion between the 5'UTR and intron 3 of gsb-n, disrupting the entire open reading frame.

(He and Noll, 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:25,046,291..25,052,374 [-]

Comment:

Scer\FRT-mediated recombination between the two progenitor insertions (PBac{WH}gsb-n^f06670 and P{XP}gsb-n^d07597) has resulted in a deletion between the 5'UTR and intron 3 of gsb-n.

(He and Noll, 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die (with gsb-n^D-19A)

(He and Noll, 2013)

partially lethal - majority die (with gsb-n^f06670)

(He and Noll, 2013)

partially lethal - majority die | recessive

(He and Noll, 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryos show no obvious abnormalities in the SNa, ISN or ISNb motor axons.

(He and Noll, 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Df(2R)GGG^d13/+, gsb-n^del has lethal phenotype

(He and Noll, 2013)

Df(2R)gsb^db/+, gsb-n^del has lethal phenotype

(He and Noll, 2013)

Df(2R)gsb^db/+, gsb-n^del has abnormal neuroanatomy | embryonic stage phenotype

(He and Noll, 2013)

Df(2R)gsb/+, gsb-n^del has lethal phenotype

(He and Noll, 2013)

Phenotype Manifest In

Other

Statement

Reference

Df(2R)GGG^d13/+, gsb-n^del has larval segmental nerve branch SNa of A1-7 phenotype

(He and Noll, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Two types of SNa axon defect are seen in embryos which carry gsb-n^D-19A and are also transheterozygous for a deficiency removing both gsb-n and gsb (Df(2R)GGG^d13): a 'thin' SNa phenotype, where the axons appear thinner but the normal bifurcation of the SNa is retained (75%) and a 'bifurcation missing' phenotype where the SNa axons lack the normal bifurcation and instead project inappropriately into the lateral muscle field (16%).

(He and Noll, 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

gsb-n^del

gsbn^del

(He and Noll, 2013)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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