FB2026_03 , released September 17, 2026
Allele: Dmel\lig3
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General Information
Symbol
Dmel\lig3
Species
D. melanogaster
Name
FlyBase ID
FBal0295155
Feature type
allele
Associated gene
Dmel\lig
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Baumgartner et al., 2013)
Mutagen
ethyl methanesulfonate
(Baumgartner et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: W155term.

(Baumgartner et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,070,418..8,070,418 [+]
Nucleotide change:

G8070418A

Reported nucleotide change:

G?A

Amino acid change:

W155term | lig-PA; W155term | lig-PB; W155term | lig-PC; W155term | lig-PD; W155term | lig-PE; W155term | lig-PF; W155term | lig-PG; W155term | lig-PH; W155term | lig-PI; W155term | lig-PJ; W155term | lig-PK; W155term | lig-PL

Reported amino acid change:

W155term

Comment:

TGG to TGA nonsense mutation in codon W155.

(Baumgartner et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lig3 mutant eyes, generated by eyFLP/FRT-mediated mitotic recombination, are bigger than controls and consist of more ommatidia.

      Mutants transheterozygous with ligPP1 or Df(2R)Exel7094 die in an early pupal stage forming long and slender pupae.

      (Baumgartner et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      lig3 is rescued by lig+t12

      (Baumgartner et al., 2013)
      Not rescued by

      lig3 is not rescued by ligt12

      (Baumgartner et al., 2013)
      Comments

      lig+t12, but not ligt12, rescues the lethality and clonal overgrowth phenotype associated with lig3.

      (Baumgartner et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lig3
      (Baumgartner et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)