FB2026_02 , released June 18, 2026
Allele: Dmel\Rab3-GAPMI11001
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General Information
Symbol
Dmel\Rab3-GAPMI11001
Species
D. melanogaster
Name
FlyBase ID
FBal0295216
Feature type
allele
Associated gene
Dmel\Rab3-GAP
Associated Insertion(s)
Mi{MIC}Rab3-GAPMI11001
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}Rab3-GAPMI11001
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Warburg micro syndrome
        CEA
        (Takáts et al., 2021)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Rab3-GAPMI11001/Df(2L)ED761 adults show a progressive decrease in climbing activity. In starved larvae, fat body cells exhibit autophagosome clusters and autolysosomes inter-connected by simple connecting points or bridge-like structures.

        3h-starved Rab3-GAPMI11001 homozygous third instar larvae exhibit peri-nuclear redistribution of lysosomes, autolysosomes and autophagosome in the fat body, as compared to controls.

        In 3h-starved third instar larvae, Rab3-GAPMI11001 clones in the fat body exhibit peri-nuclear redistribution of lysosomes, and more numerous but smaller late endosomes/lysosomes, as compared to controls.

        (Takáts et al., 2021)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Rab3-GAPMI11001
        (Bellen, 2014.3.24)
        Rab3GAP2[MI]
        (Takáts et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)