FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CkIIαK66M.UAS.N.Tag:HA
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General Information
Symbol
Dmel\CkIIαK66M.UAS.N.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0295272
Feature type
allele
Associated gene
Dmel\CkIIα
Associated Insertion(s)
Carried in Construct
P{UAS-CkIIα.K66M}
Key Links
Transgenic product class
missense_variant
(Bulat et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bulat et al., 2014)
Mutagen
in vitro construct
(Bulat et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-CkIIα.K66M}
Cytology
Description

Amino acid replacement: K66M.

(Bulat et al., 2014)

UAS regulatory sequences drive expression of kinase-dead CkIIα tagged at the N-terminal with Tag:HA.

(Bulat et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
CkIIα
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Presynaptic expression of CkIIαK66M.Scer\UAS.N.T:Ivir\HA1 in Ank2f02001 homozygous mutants enhances the synaptic retraction phenotype.

      (Bulat et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4elav-C155/CkIIαK66M.UAS.N.Tag:HA fails to rescue CkIIαLL05896

      (Bulat et al., 2014)

      Scer\GAL4da.G32/CkIIαK66M.UAS.N.Tag:HA fails to rescue CkIIαLL05896

      (Bulat et al., 2014)
      Comments

      Expression of CkIIαScer\UAS.N.T:Ivir\HA1 in the nervous system, under the control of Scer\GAL4elav-C155, fails to rescue the synapse retraction phenotype seen in CkIIαP1 homozygous neuromuscular junctions.

      (Bulat et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CkIIαK66M.Scer\UAS.N.T:Ivir\HA1
      CkIIαK66M.UAS.N.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)