FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ppk293'UTR.UAS
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General Information
Symbol
Dmel\ppk293'UTR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0295770
Feature type
allele
Associated gene
Dmel\ppk29
Associated Insertion(s)
Carried in Construct
P{UAS-ppk29.3'UTR}
Key Links
Transgenic product class
wild_type
(Zheng et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Zheng et al., 2014)
Mutagen
in vitro construct
(Zheng et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-ppk29.3'UTR}
Cytology
Description

UASt regulatory sequences drive expression of the ppk29-PD variant (NP_001097442) plus its 3'UTR.

(Zheng et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
ppk29
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing ppk293'UTR.Scer\UAS under the control of Scer\GAL4elav-C155 show more rapid paralysis in response to acute heat stress than wild-type controls.

      Flies expressing ppk293'UTR.Scer\UAS under the control of Scer\GAL4elav.Switch.PO during the adult stage only (using RU486 to control the timing of expression) show more rapid paralysis in response to acute heat stress than wild-type controls.

      (Zheng et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Scer\GAL4elav-C155, ppk293'UTR.UAS has paralytic | adult stage | heat sensitive phenotype, suppressible by Dcr-2UAS.cDa, Scer\GAL4elav-C155

      (Zheng et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The more rapid paralysis in response to acute heat stress seen in flies expressing ppk293'UTR.Scer\UAS under the control of Scer\GAL4elav-C155 is suppressed if they are also co-expressing Dcr-2Scer\UAS.cDa.

      (Zheng et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      ppk293'UTR.UAS/Scer\GAL4elav-C155 rescues ppk29f06838

      (Zheng et al., 2014)
      Comments

      The increased time to total paralysis in response to heat stress which is seen in ppk29f06838 flies is fully rescued by expression of ppk293'UTR.Scer\UAS under the control of Scer\GAL4elav-C155.

      (Zheng et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ppk293'UTR.Scer\UAS
      ppk293'UTR.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)