FlyBase Allele Report: Dmel\spag[ΔR7]

General Information

Symbol

Dmel\spag^ΔR7

Species

D. melanogaster

Name

FlyBase ID

FBal0295843

Feature type

allele

Associated gene

Dmel\spag

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Benbahouche et al., 2014)

Progenitor genotype

Cytology

Description

Imprecise excision of P{lacW}spag^k12101 generates a deletion that removes part of spag and DnaJ-60.

(Benbahouche et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

melanotic mass phenotype (with spag^k12101)

(Benbahouche et al., 2014)

Phenotype Manifest In

embryonic/larval lymph gland (with spag^k12101)

(Benbahouche et al., 2014)

secondary lobe of embryonic/larval lymph gland (with spag^k12101)

(Benbahouche et al., 2014)

tertiary lobe of embryonic/larval lymph gland (with spag^k12101)

(Benbahouche et al., 2014)

Detailed Description

Statement

Reference

Homozygous spag^k12101 larvae die 6-7 days after egg laying, with overgrowth of the hematopoietic organs and occasional formation of melanotic pseudo-tumours. This occurs more often in the distal and secondary lobes, which are usually the smallest in wild-type larvae. All other tissue such as imaginal discs and salivary glands are reduced in size.

(Benbahouche et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

spag^ΔR7 has melanotic mass phenotype phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

In(2LR)Px⁴/spag^ΔR7 has melanotic mass phenotype phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

spag^k12101/spag^ΔR7 has melanotic mass phenotype phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

spag^k12101/spag^ΔR7 has embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

spag^k12101/spag^ΔR7 has secondary lobe of embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

spag^k12101/spag^ΔR7 has tertiary lobe of embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

spag^ΔR7 has embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

spag^ΔR7 has secondary lobe of embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

spag^ΔR7 has tertiary lobe of embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

In(2LR)Px⁴/spag^ΔR7 has embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

In(2LR)Px⁴/spag^ΔR7 has secondary lobe of embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

In(2LR)Px⁴/spag^ΔR7 has tertiary lobe of embryonic/larval lymph gland phenotype, non-suppressible by DnaJ-60^t4.3

(Benbahouche et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

The presence of DnaJ-60^t4.3 fails to suppress the lethality and developmental defects found in spag^k12101/spag^ΔR7, and spag^ΔR7/In(2LR)Px⁴ mutants.

(Benbahouche et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

spag^k12101/spag^ΔR7 is rescued by spag^+t4.3

(Benbahouche et al., 2014)

spag^k12101/spag^ΔR7 is rescued by spag^+t6.5

(Benbahouche et al., 2014)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

spag^ΔR7

(Benbahouche et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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